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Association of interferon regulatory factor 5 (IRF5) gene polymorphisms with juvenile idiopathic arthritis

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Abstract

Interferon regulatory factor 5 (IRF5) is a member of IRF family which induce signaling pathways and are involved in modulation of cell growth, differentiation, apoptosis, and immune system activity. Juvenile idiopathic arthritis (JIA) is an auto-inflammatory syndrome where the inflammatory markers are believed to play a fundamental role in its pathogenesis. In this study, we aimed to assess the association of IRF5 gene polymorphisms with susceptibility of JIA in Iranian population. Three IRF5 single-nucleotide polymorphisms (rs10954213 A/G, rs2004640 G/T, and rs3807306 G/T) were genotyped using TaqMan assays in 55 patients with JIA and 63 matched healthy individuals. The frequency of the IRF5 rs2004640 T allele was significantly higher (69 vs 45%, P value = 0.0013) in JIA group as compared to control. The frequency of the IRF5 rs 2004640 G allele was significantly higher in the control group in comparison to JIA group (54 vs 32%, P value = 0.001). Allele and genotype frequencies of the rs10954213 and rs3807306 did not show any significant difference between JIA and control group. IRF5 rs 2004640 T allele can be considered as a risk factor for the development of JIA and presence of rs 2004640 G may be act as protective factor.

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Funding

This study was supported by grant from Tehran University of Medical Sciences and Health Services (95-02-159-32298).

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Authors and Affiliations

  1. Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran

    Samira Esmaeili Reykande & Maryam Sadr

  2. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran

    Samira Esmaeili Reykande, Arezou Rezaei, Maryam Sadr & Mahsima Shabani

  3. Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, 14194, Iran

    Arezou Rezaei, Mahsima Shabani & Nima Rezaei

  4. Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA

    Farnaz Najmi Varzaneh

  5. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Baltimore, MD, USA

    Farnaz Najmi Varzaneh

  6. Division of Pediatric Rheumatology, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran

    Vahid Ziaee

  7. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Nima Rezaei

  8. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Sheffield, UK

    Nima Rezaei

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  1. Samira Esmaeili Reykande
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Correspondence to Nima Rezaei.

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Esmaeili Reykande, S., Rezaei, A., Sadr, M. et al. Association of interferon regulatory factor 5 (IRF5) gene polymorphisms with juvenile idiopathic arthritis. Clin Rheumatol 37, 2661–2665 (2018). https://doi.org/10.1007/s10067-018-4010-9

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  • DOI: https://doi.org/10.1007/s10067-018-4010-9

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