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Clinical Rheumatology

, Volume 36, Issue 10, pp 2365–2370 | Cite as

Association of obesity with patient-reported outcomes in patients with axial spondyloarthritis: a cross-sectional study in an urban Asian population

  • Yi Xuan Lee
  • Yu Heng Kwan
  • Wan Yu Png
  • Ka Keat Lim
  • Chuen Seng Tan
  • Nai Lee Lui
  • Eng Hui Chew
  • Julian Thumboo
  • Truls Østbye
  • Warren FongEmail author
Brief Report

Abstract

To determine if obesity is associated with poorer patient-reported outcomes (PROs) in patients with axial spondyloarthritis (axSpA), we conducted a cross-sectional study using data of the PRESPOND registry from a tertiary referral center in Singapore between 2011 and 2015. Demographics, clinical, and PRO variables were collected. Patients were divided into three categories: normal (BMI < 23 kg/m2), overweight (23 kg/m2 ≤ BMI < 27.5 kg/m2) and obese (BMI ≥ 27.5 kg/m2), using Asian BMI classification. The dependent variables are Pain score, Bath Ankylosing Spondylitis Patient Global Score (BAS-G), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), Health Assessment Questionnaire (HAQ), and Medical Outcomes Study Short Form 36 version 2 (SF-36). Multivariate regression analyses were performed with these dependent variables and obesity categories, adjusting for confounders. Among 194 patients with axSpA, 32% are overweight while 22% are obese. We found that obese patients had significant poorer pain (β: 11.87, 95%CI 2.13, 21.60) and BAS-G scores (β: 10.18, 95%CI 1.59, 18.76) when compared to normal BMI patients. However, obesity was not associated with BASDAI (β 0.50, 95%CI -0.22, 1.22), BASFI (β 0.08, 95%CI -0.66, 0.81), HAQ (β -0.07, 95%CI -0.21, 0.06), physical component summary (β -0.02, 95%CI -4.47, 4.44), and mental component summary (β -2.85, 95%CI -7.57, 1.88) of SF-36. Obesity was associated with pain score and BAS-G but not with BASDAI, BASFI, HAQ, and SF-36. Further study is needed to examine the causal relationship between obesity and poorer PROs.

Keywords

Disease outcomes Global Obesity Pain Spondyloarthritis 

Notes

Compliance with ethical standards

Disclosure

None.

Supplementary material

10067_2017_3585_MOESM1_ESM.docx (63 kb)
Supplementary Tables (DOCX 62.5 kb)

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Copyright information

© International League of Associations for Rheumatology (ILAR) 2017

Authors and Affiliations

  1. 1.Department of PharmacyNational University of SingaporeSingaporeSingapore
  2. 2.Program in Health Services and Systems ResearchDuke-NUS Medical SchoolSingaporeSingapore
  3. 3.Saw Swee Hock School of Public HealthNational University of SingaporeSingaporeSingapore
  4. 4.Department of Rheumatology and ImmunologySingapore General HospitalSingaporeSingapore
  5. 5.Duke-NUS Medical SchoolSingaporeSingapore
  6. 6.Department of Medicine, Yong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore

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