Skip to main content

Advertisement

SpringerLink
Log in

RAPID3 scores and hand outcome measurements in RA patients: a preliminary study

  • Brief Report
  • Published:
Clinical Rheumatology Aims and scope Submit manuscript

Abstract

The Routine Assessment of Patient Index Data 3 (RAPID3) is a patient-reported disease activity measure used to assess physical function, pain, and global health in patients with rheumatoid arthritis (RA) without formal joint counts. Since hand involvement and its decreased function are hallmarks of RA, the aim of our study was to investigate the performance of RAPID3 scores with regard to hand function and to confirm previous findings that the RAPID3 score as a disease activity measure is strongly correlated with the DAS28 score. Sixty-eight consecutive patients with RA (85% female), aged 18–75 years, were included in the study and were recruited during their outpatient visit. Apart from demographic and clinical data, the obtained parameters of interest included RAPID3 scores and assessments of the function of the hand, namely, the signal of functional impairment (SOFI)-hand, grip strength, and pulp-to-palm distance, as well the Health Assessment Questionnaire- Disability Index (HAQ-DI) and DAS28 scores. Pearson’s correlation coefficient, Student’s t test and linear regression were used in the statistical analysis of the results. The significance was set to p < 0.05. A positive correlation was found between RAPID3 scores and HAQ-DI scores, SOFI-hand scores, and pulp-to-palm distance, and negative correlation was observed between RAPID3 scores and grip strength. The order regarding the strength of correlations between RAPID3 scores and other variables (from the strongest to the weakest) was as follows: HAQ-DI, grip strength, SOFI-hand and pulp-to-palm distance. The hand assessment variables had stronger correlations with RAPID3 scores than with DAS28 scores. Our preliminary study showed that RAPID3 scores were strongly correlated with measurements of the functional ability of the hand, demonstrating that RAPID3 can be used as a measure of disease activity in clinical practice and to characterize hand function. Further studies are needed to confirm this result.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Scott D, Wolfe F, Huizinga TWJ (2010) Rheumatoid arthritis. Lancet 376:1094–1108. doi:10.1016/S0140-6736(10)60826-4

    Article  PubMed  Google Scholar 

  2. Poole JL, Santhanam DD, Latham AL (2013) Hand impairment and activity limitations in four chronic diseases. J Hand Ther 26:232–237. doi:10.1016/j.jht.2013.03.002

    Article  PubMed  Google Scholar 

  3. Andrade JABM, Pinto MR, Lanna CC (2016) Factors associated with activity limitations in people with rheumatoid arthritis. Am J OccupTher 70:1–7. doi:10.5014/ajot.2016.017467

    Google Scholar 

  4. Choy E (2012) Understanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritis. Rheumatology (Oxford) 51:v3–11. doi:10.1093/rheumatology/kes113

    Article  CAS  Google Scholar 

  5. Pincus T, Swearingen CJ, Bergman MJ, Colglazier CL, Kaell AT, Kunath AM, Siegel EL, Yazici Y (2010) RAPID3 (routine assessment of patient index data) on an MDHAQ (multidimensional health assessment questionnaire): agreement with DAS28 (disease activity score) and CDAI (clinical disease activity index) activity categories, scored in five versus more than ninety seconds. Arthritis Care Res (Hoboken) 62:181–189. doi:10.1002/acr.20066

    Article  Google Scholar 

  6. Kim SK, Park SH, Bae J, Son JT, Choe JY (2014) Performance of routine assessment of patient index data 3 (RAPID3) for assessment of rheumatoid arthritis in clinical practice: differential agreement of RAPID3 according to disease activity categories. RheumatolInt 34:1311–1318. doi:10.1007/s00296-014-3042-y

    Article  Google Scholar 

  7. Eberhardt K, Sandqvist G, Geborek P (2008) Hand function tests are important and sensitive tools for assessment of treatment response in patients with rheumatoid arthritis. Scand J Rheumatol 37:109–112. doi:10.1080/03009740701747129

    Article  CAS  PubMed  Google Scholar 

  8. Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO 3rd, Birnbaum NS, Burmester GR, Bykerk VP, Cohen MD, Combe B, Costenbader KH, Dougados M, Emery P, Ferraccioli G, Hazes JM, Hobbs K, Huizinga TW, Kavanaugh A, Kay J, Kvien TK, Laing T, Mease P, Ménard HA, Moreland LW, Naden RL, Pincus T, Smolen JS, Stanislawska-Biernat E, Symmons D, Tak PP, Upchurch KS, Vencovský J, Wolfe F, Hawker G (2010). 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum 62:2569–81. doi:10.1002/art.27584

  9. Prevoo ML, van't Hof MA, Kuper HH, van Leuwwen MA, van der Putte LB, van Riel PL (1995) Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 38:44–48. doi:10.1002/art.1780380107

    Article  CAS  PubMed  Google Scholar 

  10. North Coast Medical & Rehabilitation Products (2013) https://www.ncmedical.com/item_699.html Accessed 15 September 2013

  11. Mathiowetz V, Kashman N, Volland G, Weber K, Dowe M, Rogers S (1985) Grip and pinch strength: normative data for adults. Arch Phys Med Rehabil 66:69–74

    CAS  PubMed  Google Scholar 

  12. Eberhardt KB, Svensson B, Moritz U (1988) Functional assessment of early rheumatoid arthritis. Br J Rheumatol 27:364–371. doi:10.1093/rheumatology/27.5.364

    Article  CAS  PubMed  Google Scholar 

  13. Macey AC, Burke FD (1995) Outcome of hand surgery. J Hand Surg Eur 20:841–855. doi:10.1016/S0266-7681(95)80059-X

    Article  CAS  Google Scholar 

  14. Fries J, Kraines R, Holman H (1980) Measurement of patient outcome in arthritis. Arthritis Rheum 23:137–145. doi:10.1002/art.1780230202

    Article  CAS  PubMed  Google Scholar 

  15. Dedeoglu M, Gafuroglu U, Yilmaz O, Bodur H (2013) The relationship between hand grip and pinch strengths and disease activity, articular damage, pain, and disability in patients with rheumatoid arthritis. Turk J Rheumatol 28:69–78. doi:10.5606/tjr.2013.2742

    Article  Google Scholar 

  16. Hallert E, Bjork M, Dahlstrom O, Skogh T, Thyberg I (2012) Disease activity and disability in women and men with early rheumatoid arthritis (RA): an 8-year followup of a Swedish early RA project. Arthritis Care & Research 64:1101–1107

    Google Scholar 

  17. Hakkinen A, Kautiainen H, Hannonen P, Ylinen J, Makinen H, Sokka T (2006) Muscle strength, pain, and disease activity explain individual subdimensions of the health assessment questionnaire disability index, especially in women with rheumatoid arthritis. Ann Rheum Dis 65:30–34. doi:10.1136/ard.2004.034769

    Article  CAS  PubMed  Google Scholar 

  18. Adams J, Burridge J, Mullee M, Hammond A, Cooper C (2004) Correlation between upper limb functional ability and structural hand impairment in an early rheumatoid population. Clin Rehabil 18:405–413. doi:10.1191/0269215504cr732oa

    Article  CAS  PubMed  Google Scholar 

  19. Sheehy C, Gaffney K, Mukhtyar C (2013) Standardized grip strength as an outcome measure in early rheumatoid arthritis. Scand J Rheumatol 42:289–293. doi:10.3109/03009742.2012.747624

  20. Piquer PN, Palomares CN, Cortes JI, Grau E, Verdejo IC, Almela CM (2014) Relationship between HAQ, DAS28 and radiological damage with functional capacity of the hand in rheumatoid arthritis. Ann Rheum Dis 73:879–880. doi:10.1136/annrheumdis-2014-eular.4977

    Google Scholar 

  21. Bircan C, Gunduz NE, Tekgul A, Cetin P, Onen F, Kizil R, Gulbahar S (2014) Grip ability test in rheumatoid arthritis patients: relationship with disease activity and hand-specific self-report questionnaires. Turk J Rheumatol 29:160–167. doi:10.5606/tjr.2014.4590

    Google Scholar 

  22. Kapetanovic MC, Lindqvist E, Nilsson J-Å, Geborek P, Saxne T, Eberhardt K (2015) Development of functional impairment and disability in rheumatoid arthritis patients followed for 20 years: relation to disease activity, joint damage, and comorbidity. Arthritis Care Res (Hoboken) 67:340–348. doi:10.1002/acr.22458

    Article  Google Scholar 

  23. Lopez Lopez CO, Alvarez-Hernandez E, Medrano Ramirez G, Montes Castillo ML, Hernandez-Diaz C, Ventura Rios L, Arreguin Lopez R, Vazquez-Mellado J (2014) Hand function in rheumatic diseases: patient and physician evaluations. Int J Rheum Dis 17:856–862. doi:10.1111/1756-185X.12466

    Article  PubMed  Google Scholar 

  24. Bjork MA, Thyberg IS, Skogh T, Gerdle BU (2007) Hand function and activity limitation according to health assessment questionnaire in patients with rheumatoid arthritis and healthy referents: 5-year followup of predictors of activity limitation (the Swedish TIRA project). J Rheumatol 34:296–302

    PubMed  Google Scholar 

  25. Bjork M, Thyberg I, Haglund L, Skogh T (2006) Hand function in women and men with early rheumatoid arthritis. A prospective study over three years (the Swedish TIRA project). Scand J Rheumatol 35:15–19. doi:10.1080/03009740510026562

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Clinic of Physical Medicine and Rehabilitation, University Clinical Centre of Kosova, Prishtina, Kosova, Republic of Kosovo

    Merita Qorolli & Hajrije Hundozi-Hysenaj

  2. Rheumatology Clinic, University Clinical Centre of Kosova, Prishtina, Kosova, Republic of Kosovo

    Sylejman Rexhepi & Blerta Rehxepi

  3. University Department for Rheumatology, Physical and Rehabilitation Medicine, Clinical Hospital Centre Sisters of Mercy, Vinogradska c. 29, 10000, Zagreb, Croatia

    Simeon Grazio

Authors
  1. Merita Qorolli
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hajrije Hundozi-Hysenaj
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sylejman Rexhepi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Blerta Rehxepi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Simeon Grazio
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Simeon Grazio.

Ethics declarations

Disclosures

None.

Funding

None

Electronic supplementary material

ESM 1

(DOCX 12 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Qorolli, M., Hundozi-Hysenaj, H., Rexhepi, S. et al. RAPID3 scores and hand outcome measurements in RA patients: a preliminary study. Clin Rheumatol 36, 1379–1385 (2017). https://doi.org/10.1007/s10067-016-3514-4

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10067-016-3514-4

Keywords

Search

Navigation