Clinical Rheumatology

, Volume 36, Issue 1, pp 155–163 | Cite as

Depressive symptoms and structural disease progression in knee osteoarthritis: data from the Osteoarthritis Initiative

  • Alan M. Rathbun
  • Michelle S. Yau
  • Michelle Shardell
  • Elizabeth A. Stuart
  • Marc C. Hochberg
Original Article
First Online:
Received:
Accepted:

Abstract

Depressive symptoms are associated with increases in pain and functional limitations in knee osteoarthritis (OA). The aim was to determine whether depressive symptoms are also associated with greater structural knee OA progression. Four years of annual radiographic and clinical assessments from the Osteoarthritis Initiative were analyzed. The Center for Epidemiological Studies Depression Scale was used to identify depressive symptoms (threshold = ≥16) at the baseline visit. Propensity scores were used to match participants with and without baseline depressive symptoms on multiple potential confounders. Assessment of radiographic knee OA was based on changes in individual radiographic features, which included osteophyte (OST) grade and joint space narrowing (JSN) grade. Mixed effect models were used to examine structural progression between depressed and non-depressed participants with definitive radiographic knee OA. Depressive symptoms were significantly associated with a higher risk of OST progression (odds ratio [OR] = 1.74; 95% confidence interval [CI]: 1.01, 3.00) and a non-significant lower risk of JSN progression (OR = 0.40; 95% CI: 0.14, 1.15) 1 year after baseline. Conversely, there was a non-significant lower risk of OST progression (OR = 0.71; 95% CI: 0.28, 1.79) and higher risk of JSN progression (OR = 1.89; 95% CI: 0.71, 5.06) from year 3 to year 4 of follow-up. However, the patterns of OST progression and JSN progression were not significantly different between the depressed and non-depressed (P = 0.25 and 0.15, respectively). The findings provide no evidence that depressive symptoms have a detectable effect on changes in radiographic disease severity in knee OA.

Keywords

Bone Cartilage Epidemiology Osteoarthritis 
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Notes

Acknowledgements

The OAI is a public-private partnership composed of five contracts (N01-AR-2-2258; N01-AR-2-2259; N01-AR-2-2260; N01-AR-2-2261; N01-AR-2-2262) funded by the National Institutes of Health, a branch of the Department of Health and Human Services, and conducted by the OAI Study Investigators. Private funding partners include Merck Research Laboratories; Novartis Pharmaceuticals Corporation, GlaxoSmithKline; and Pfizer, Inc. Private sector funding for the OAI is managed by the Foundation for the National Institutes of Health. This manuscript was prepared using an OAI public use data set and does not necessarily reflect the opinions or views of the OAI investigators, the NIH, or the private funding partners.

Compliance with ethical standards

Disclosures

None.

Funding

This research was supported by a training grant (T32 AG000262) from the National Institute on Aging.

Supplementary material

10067_2016_3495_MOESM1_ESM.docx (53 kb)
ESM 1 (DOCX 52 kb)

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Copyright information

© International League of Associations for Rheumatology (ILAR) 2016

Authors and Affiliations

  • Alan M. Rathbun
    • 1
  • Michelle S. Yau
    • 2
  • Michelle Shardell
    • 3
  • Elizabeth A. Stuart
    • 4
  • Marc C. Hochberg
    • 5
  1. 1.Department of Epidemiology and Public HealthUniversity of Maryland School of MedicineBaltimoreUSA
  2. 2.Harvard Medical SchoolHebrew SeniorLife Institute for Aging ResearchBostonUSA
  3. 3.Translational Gerontology BranchNational Institutes on AgingBethesdaUSA
  4. 4.Johns Hopkins University Bloomberg School of Public HealthBaltimoreUSA
  5. 5.Division of Rheumatology and Clinical Immunology, Department of MedicineUniversity of Maryland School of MedicineBaltimoreUSA

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