Clinical Rheumatology

, Volume 35, Issue 8, pp 1967–1975 | Cite as

Evaluation of cardiac functions in juvenile systemic lupus erythematosus with two-dimensional speckle tracking echocardiography

  • Reyhan DedeogluEmail author
  • Sezgin Şahin
  • Aida Koka
  • Funda Öztunç
  • Amra Adroviç
  • Kenan Barut
  • Dicle Cengiz
  • Özgür Kasapçopur
Original Article


The aim of this study was to investigate subclinical systolic and diastolic dysfunction in juvenile-onset systemic lupus erythematosus (j-SLE) patients with speckle tracking echocardiography (STE) and the effects of disease activity on left ventricular (LV) regional functions. Thirty-five patients with j-SLE and 30 healthy children (control group) were evaluated between January and August 2015. STE was performed on all patients and controls. Medical records, including diagnosis criteria, age at diagnosis, and duration of disease, were evaluated. SLE disease activity was assessed using the SLE Disease Activity Index (SLEDAI). j-SLE patients had lower ejection fraction than did control subjects but still within normal range. LV end-diastolic and end-systolic dimensions were significantly larger in j-SLE patients (32.43 ± 3.2 vs 28.3 ± 3.1 and 21.1 ± 1.9 vs 18.9.0 ± 2.2, respectively; p = 0.001). There was a significant reduction in longitudinal strain of LV segments in the j-SLE patients compared with controls. J-SLE patients were further divided into subgroups. Group 1 comprised patients having SLEDAI scores >8 at the onset of disease but who improved with therapy during follow-up. Group 2 included j-SLE patients with SLEDAI scores >8 at diagnosis and persistently >4 at the end of follow-up. In the LV mid-inferior and mid-inferolateral segments, STE strain measurements of group 2 were significantly lower than those of group 1 (15.9 ± 6.4 vs 20.0 ± 4.4, 17.9 ± 7.2 vs 23.2 ± 3.8; p = 0.075, p = 0.055, respectively). Simple and non-invasive STE would be helpful in predicting cardiovascular prognosis with new therapeutic medications/interventions or in objectively comparing the effects of immunosuppressive drugs in comparison with preceding STE evaluation.


j-SLE SLEDAI Speckle tracking echocardiography Systolic dysfunction Systolic strain 


Compliance with ethical standards

All patients and their families were informed, and written informed consent was obtained. The ethics committee of our institution approved the study. All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000 and 2008.




No funding was received from any public, special commercial sectors for this manuscript.


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Copyright information

© International League of Associations for Rheumatology (ILAR) 2016

Authors and Affiliations

  • Reyhan Dedeoglu
    • 1
    Email author
  • Sezgin Şahin
    • 2
  • Aida Koka
    • 1
  • Funda Öztunç
    • 1
  • Amra Adroviç
    • 2
  • Kenan Barut
    • 2
  • Dicle Cengiz
    • 3
  • Özgür Kasapçopur
    • 2
  1. 1.Pediatric Cardiology, Cerrahpasa Medical Faculty, Department of Pediatric CardiologyIstanbul UniversityIstanbulTurkey
  2. 2.Pediatric Rheumatology, Cerrahpasa Medical Faculty, Department of Pediatric CardiologyIstanbul UniversityIstanbulTurkey
  3. 3.Department of StatisticsIstanbul Commerce UniversityIstanbulTurkey

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