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Clinical Rheumatology

, Volume 35, Issue 10, pp 2397–2401 | Cite as

Comparison of three classification criteria of rheumatoid arthritis in an inception early arthritis cohort

  • Hua Ye
  • Yin SuEmail author
  • Ru Li
  • Jinxia Zhao
  • Xiangyuan Liu
  • Yifang Mei
  • Zhiyi Zhang
  • Jialong Guo
  • Liqi Bi
  • Xia Liu
  • Guochun Wang
  • Jinjing Liu
  • Xiaomei Leng
  • Fei Gu
  • Lingyun Sun
  • Qinghua Zou
  • Yongfei Fang
  • Quan Jiang
  • Zhanguo LiEmail author
Original Article

Abstract

The aim of this study is to compare the three classification criteria for rheumatoid arthritis (RA) in a large cohort of early arthritis patients. Patients who had at least one clinically swollen joint with disease duration no more than 1 year and age more than 18 years were enrolled. The clinical and laboratory parameters were recorded. The patients were diagnosed by two experienced rheumatologists. Undiagnosed patients were followed up every 3 months until 1 year. The sensitivity, specificity, and predictive value were compared among the early RA (ERA) criteria, the 1987 ACR criteria, and the 2010 ACR/EULAR criteria in this inception cohort of early arthritis patients. A total of 417 patients with inflammatory arthritis were recruited. By the end of 1 year follow-up, there were 399 patients (95.7 %) with a definitive diagnosis and 18 (4.3 %) patients remained as undifferentiated arthritis. Among the patients with definitive diagnosis, 202 (50.6 %) patients were diagnosed with RA and 197 (49.4 %) with non-RA. The sensitivity of ERA criteria was equal to 2010 ACR/EULAR criteria (both were 72.3 %), but much higher than 1987 ACR criteria (72.3 vs. 39.1 %, P < 0.001); the specificity of ERA criteria was comparable to 2010 ACR/EULAR criteria (87.8 vs. 83.2 %) and slightly lower than 1987 ACR criteria (87.8 vs. 92.4 %, P < 0.001). Unlike the complicated scoring system of 2010 criteria, the ERA criteria were more feasible to use in practice with five criteria only. The ERA criteria have a high sensitivity and more clinically feasibility in daily practice for early RA diagnosis.

Keywords

Arthritis Classification criteria Early Rheumatoid 

Notes

Acknowledgments

This work was supported by key projects of the national science & technology pillar program during the 11th 5-year plan period (2008BAI59B01), National Basic Research Program of China (973 program) (2010CB529100), and grants from the National Natural Science Foundation of China (no. 81030057).

Compliance with ethical standards

Disclosures

None.

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Copyright information

© International League of Associations for Rheumatology (ILAR) 2016

Authors and Affiliations

  • Hua Ye
    • 1
  • Yin Su
    • 1
    Email author
  • Ru Li
    • 1
  • Jinxia Zhao
    • 2
  • Xiangyuan Liu
    • 2
  • Yifang Mei
    • 3
  • Zhiyi Zhang
    • 3
  • Jialong Guo
    • 4
  • Liqi Bi
    • 4
  • Xia Liu
    • 5
  • Guochun Wang
    • 5
  • Jinjing Liu
    • 6
  • Xiaomei Leng
    • 6
  • Fei Gu
    • 7
  • Lingyun Sun
    • 7
  • Qinghua Zou
    • 8
  • Yongfei Fang
    • 8
  • Quan Jiang
    • 9
  • Zhanguo Li
    • 1
    Email author
  1. 1.Department of Rheumatology & ImmunologyPeking University People’s HospitalBeijingChina
  2. 2.Department of Rheumatology & ImmunologyPeking University Third HospitalBeijingChina
  3. 3.Department of Rheumatology & Immunology of the First Affiliated Hospital of Harbin Medical UniversityHarbinChina
  4. 4.Department of Rheumatology & ImmunologyChina-Japan Union Hospital of Jilin UniversityChangchunChina
  5. 5.Department of Rheumatology & ImmunologyChina-Japan Friendship HospitalBeijingChina
  6. 6.Department of Rheumatology & ImmunologyPeking Union Medical College HospitalBeijingChina
  7. 7.Department of Rheumatology & Immunology of the Affiliated Drum Tower HospitalNanjing UniversityNanjingChina
  8. 8.Department of Rheumatology & ImmunologySouthwest Hospital of Third Military Medical UniversityChongqingChina
  9. 9.Guang An Men Hospital of Academy of Traditional Chinese MedicineBeijingChina

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