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Clinical Rheumatology

, Volume 34, Issue 11, pp 1989–1992 | Cite as

Hyperferritinemic syndrome: Still’s disease and catastrophic antiphospholipid syndrome triggered by fulminant Chikungunya infection: a case report of two patients

  • Juan-Felipe Betancur
  • Erika-Paola Navarro
  • Alex Echeverry
  • Pablo A. Moncada
  • Carlos A. Cañas
  • Gabriel J. Tobón
Case Based Review

Abstract

There are four medical conditions characterized by high levels of ferritin, the macrophage activation syndrome (MAS), adult onset Still’ s disease (AOSD), catastrophic antiphospholipid syndrome (CAPS), and septic shock, that share similar clinical and laboratory features, suggesting a common pathogenic mechanism. This common syndrome entity is termed “the hyperferritinemic syndrome.” Here, we describe two different cases of hyperferritinemic syndrome triggered by Chikungunya fever virus infection: a 21-year-old female with SLE and a 32-year-old male patient who developed AOSD after the coinfection of dengue and Chikungunya viruses.

Keywords

Adult onset Still’s disease Catastrophic antiphospholipid syndrome Chikungunya virus infection Ferritin Hyperferritinemic syndrome 

Notes

Disclosures

None.

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Copyright information

© International League of Associations for Rheumatology (ILAR) 2015

Authors and Affiliations

  • Juan-Felipe Betancur
    • 1
  • Erika-Paola Navarro
    • 1
  • Alex Echeverry
    • 2
  • Pablo A. Moncada
    • 3
  • Carlos A. Cañas
    • 2
  • Gabriel J. Tobón
    • 2
    • 4
  1. 1.Department of Internal MedicineCES University, School of Medicine, Medellín-Colombia and Fundación Valle del LiliCaliColombia
  2. 2.Rheumatology Unit. Fundación Valle del LiliIcesi UniversityCaliColombia
  3. 3.Infectious Diseases Unit. Fundación Valle del LiliCaliColombia
  4. 4.Laboratory of Immunology. Fundación Valle del LiliCaliColombia

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