Is there any link between joint hypermobility and mitral valve prolapse in patients with fibromyalgia syndrome?
- 256 Downloads
The objective of the present study is to determine whether benign joint hypermobility syndrome (BJHS) modifies the risk of mitral valve prolapse (MVP) in patients with fibromyalgia (FM). Female patients fulfilling the 1990 American College of Rheumatology (ACR) diagnostic criteria for FM were included into the study. Joint hypermobility and BJHS were assessed using Beighton’s scoring system and Brighton criteria, respectively. Echocardiograpic evaluation was performed in order to test the presence of MVP. Of the 75 female FM patients, 68.0 % (n = 51) and 20.0 % (n = 15) were diagnosed with BJHS and MVP, respectively. The frequencies of both MVP and BJHS seemed higher than the general population prevalence (p = 0.000 for both). The frequency of MVP was significantly higher in patients with BJHS than that in patients without BJHS (p = 0.028). In addition, BJHS was found to increase the risk of MVP approximately ninefold [odds ratio (OR) 8.7, 95 % confidence interval (CI) 1.1–70.7]. As a result, BJHS and MVP are both common in female patients with FM. Moreover, among the female patients with FM, those with BJHS are about nine times more prone to MVP than those without BJHS. Cardiologic assessment might be added to the routine follow-up strategies in FM patients with BJHS in order to exclude the cardiac pathologies, especially MVP.
KeywordsBenign joint hypermobility syndrome Fibromyalgia Fibromyalgia syndrome Joint hypermobility Mitral valve prolapse
We thank Prof. and Dr. Gulsah Seydaoglu who contributed significantly on the statistical analysis of the study.
Conflict of interest
- 1.Pellegrino MJ, Van Fossen D, Gordon C, Ryan JM, Waylonis GW (1989) Prevalence ofmitral valveprolapse in primaryfibromyalgia: a pilot investigation. Arch PhysMed Rehabil 70:541–543Google Scholar
- 2.Jones GT, Atzeni F, Beasley M, Flüß E, Sarzi-Puttini P, Macfarlane GJ (2015) The prevalence of fibromyalgia in the general population: a comparison of the american college of rheumatology 1990, 2010, and modified 2010 classification criteria. Arthritis Rheumatol 67:568–575CrossRefPubMedGoogle Scholar
- 4.Ofluoglu D, Gunduz OH, Kul-Panza E, Guven Z (2006) Hypermobility in women with fibromyalgia syndrome. ClinRheumatol 25:291–293Google Scholar
- 5.Ofluoglu D, Panza-Kul E, Gunduz OH, Guven Z (2004) The frequency of clinical signs in patients with fibromyalgia syndrome and the relationship between fibromyalgia syndrome and hypermobility. Turk J Phys Med Rehab 50:9–12Google Scholar
- 8.Güvenç TS, Canga Y, Karabağ Y, Ozen K, Balcı B (2012) Prevalence of mitral valveprolapse in residentsliving at moderatelyhighaltitude. WildernessEnvironMed 23:300–306Google Scholar
- 11.Grahame R, Bird HA, Child A (2000) The revised (Brighton 1998) criteria for the diagnosis of benign joint hypermobility syndrome (BJHS). J Rheumatol Jul 27:1777–1779Google Scholar
- 13.ACC/AHA guidelines for the management of patients with valvular heart disease. A report of the American College of Cardiology/American Heart Association. Task Force on Practice Guidelines (Committee on Management of Patients With Valvular Heart Disease (2006) J Am CollCardio l48:1-148.Google Scholar
- 22.Rahman A, Underwood M, Carnes D (2014) Fibromyalgia. BMJ348:g1224.Google Scholar
- 23.Hinkes B, Hilgers KF, Bolz HJ, Goppelt-Struebe M, Amann K, Nagl S, et al. (2012) A complex microdeletion 17q12 phenotype in a patient with recurrent de novo membranous nephropathy. BMC Nephrol13:27.Google Scholar