Clinical Rheumatology

, Volume 34, Issue 4, pp 615–628 | Cite as

MicroRNAs in rheumatoid arthritis

  • Eisa Salehi
  • Rahil Eftekhari
  • Mona Oraei
  • Alvand Gharib
  • Katayoon Bidad
Review Article


The role of genetic and epigenetic factors in the development of rheumatic diseases has been an interesting field of research over the past decades all around the world. Research on the role of microRNAs (miRNAs) in rheumatoid arthritis (RA) has been active and ongoing, and investigations have attempted to use miRNAs as biomarkers in disease diagnosis, prognosis, and treatment. This review focuses on experimental researches in the field of miRNAs and RA to present the data available up to this date and includes researches searched by keywords “microRNA” and “rheumatoid arthritis” in PubMed from 2008 to January 2015. All references were also searched for related papers. miRNAs are shown to act as proinflammatory or anti-inflammatory agents in diverse cell types, and their role seems to be regulatory in most instances. Researchers have evaluated miRNAs in patients compared to controls or have investigated their role by overexpressing or silencing them. Multiple targets have been identified in vivo, in vitro, or in silico, and the researches still continue to show their efficacy in clinical settings.


Autoimmunity Biomarkers Immunology Inflammation MicroRNA miRNA Rheumatoid arthritis 


Conflict of interest



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Copyright information

© International League of Associations for Rheumatology (ILAR) 2015

Authors and Affiliations

  • Eisa Salehi
    • 1
  • Rahil Eftekhari
    • 1
  • Mona Oraei
    • 2
  • Alvand Gharib
    • 3
  • Katayoon Bidad
    • 4
  1. 1.Immunology Department, School of MedicineTehran University of Medical SciencesTehranIran
  2. 2.Immunology Department, School of Public HealthTehran University of Medical SciencesTehranIran
  3. 3.Naamdar Medical Diagnostic LabTehran University of Medical SciencesTehranIran
  4. 4.Immunology, Asthma and Allergy Research InstituteTehran University of Medical SciencesTehranIran

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