Clinical Rheumatology

, Volume 33, Issue 7, pp 1009–1013 | Cite as

Dermatologic manifestations of fibromyalgia

  • Valerie Laniosz
  • David A. Wetter
  • Desiree A. Godar
Brief Report

Abstract

The aim of this study was to determine the common dermatologic diagnoses and skin-related symptoms in a cohort of patients with fibromyalgia seen in a tertiary referral center. A retrospective chart review was performed of all patients with a fibromyalgia diagnosis from January 1 to December 31, 2008, whose diagnosis was confirmed in the Fibromyalgia and Chronic Fatigue Clinic at Mayo Clinic in Rochester, Minnesota. Charts were reviewed for dermatologic conditions and cutaneous symptoms. Demographic and clinical data were collected to assess the frequency of skin-related issues in patients with fibromyalgia. Of 2,233 patients screened, 845 patients met the inclusion criteria of having a confirmed diagnosis of fibromyalgia. Among these fibromyalgia patients, various dermatologic conditions and cutaneous problems were identified, including hyperhidrosis in 270 (32.0 %), burning sensation of the skin or mucous membranes in 29 (3.4 %), and various unusual cutaneous sensations in 14 (1.7 %). Pruritus without identified cause was noted by 28 patients (3.3 %), with another 16 patients (1.9 %) reporting neurotic excoriations, prurigo nodules, or lichen simplex chronicus. Some form of dermatitis other than neurodermatitis was found in 77 patients (9.1 %). Patients with fibromyalgia may have skin-related symptoms associated with their fibromyalgia. No single dermatologic diagnosis appears to be overrepresented in this population, with the exception of a subjective increase in sweating.

Keywords

Cutaneous dysesthesia Dermatology Fibromyalgia Hyperhidrosis 

References

  1. 1.
    Beritze N, Arguelles M, Carcaba V, Fernandez F, Janciauskiene S, Oikonomopoulou K, Serres F, Fernandez-Bustillo E, Hollenberg M (2010) Abnormal overexpression of mastocytes in skin biopsies of fibromyalgia patients. Clin Rheumatol 29(12):10p. doi:10.1007/s10067-010-1474-7 Google Scholar
  2. 2.
    Salemi S, Rethage J, Wollina U, Michel BA, Gay RE, Gay S, Sprott H (2003) Detection of interleukin 1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha in skin of patients with fibromyalgia. J Rheumatol 30(1):146–150PubMedGoogle Scholar
  3. 3.
    Sprott H, Muller A, Heine H (1998) Collagen cross-links in fibromyalgia syndrome. Z Rheumatol 57(Suppl 2):52–55PubMedCrossRefGoogle Scholar
  4. 4.
    Jeschonneck M, Grohmann G, Hein G, Sprott H (2000) Abnormal microcirculation and temperature in skin above tender points in patients with fibromyalgia. Rheumatology (Oxford) 39(8):917–921CrossRefGoogle Scholar
  5. 5.
    Morf S, Amann-Vesti B, Forster A, Franzeck UK, Koppensteiner R, Uebelhart D, Sprott H (2005) Microcirculation abnormalities in patients with fibromyalgia—measured by capillary microscopy and laser fluxmetry. Arthritis Res Ther 7(2):R209–R216. doi:10.1186/ar1459 PubMedCentralPubMedCrossRefGoogle Scholar
  6. 6.
    Cakir T, Evcik D, Dundar U, Yigit I, Kavuncu V (2011) Evaluation of sympathetic skin response and F wave in fibromyalgia syndrome patients. Turkish Journal of Rheumatology (Turkish League Against Rheumatism//Turkiye Romatizma Arastirma ve Savas Dernegi) 26(1):6p. doi:10.5606/tjr.2011.006 Google Scholar
  7. 7.
    Unlu E, Hamamcioglu K, Odabasi Z, Cakci A, Vural O (2006) Dysautonomia in fibromyalgia syndrome: sympathetic skin responses and RR interval analysis. Rheumatol Int 26(5):5p. doi:10.1007/s00296-005-0007-1 Google Scholar
  8. 8.
    Ulas U, Gurcay E, Tuncay R, Berber S, Cakci A, Odabasi Z (2006) Genital sympathetic skin responses in fibromyalgia syndrome. Rheumatol Int 26(11):6p. doi:10.1007/s00296-006-0131-6 Google Scholar
  9. 9.
    Yildiz M, Koklukaya E (2012) The correlation of laboratory tests and sympathetic skin response parameters by using artificial neural networks in fibromyalgia patients. J Med Syst 36(3):8p. doi:10.1007/s10916-010-9643-4 Google Scholar
  10. 10.
    Yoldas T, Yigiter R, Kaya A, Ardicoglu O (2006) R-R interval variation and sympathetic skin response in fibromyalgia. Arch Med Res 37(5):5p. doi:10.1016/j.arcmed.2005.11.008 Google Scholar
  11. 11.
    Salemi S, Aeschlimann A, Wollina U, Gay RE, Michel BA, Gay S, Sprott H (2007) Upregulation of delta-opioid receptors and kappa-opioid receptors in the skin of fibromyalgia patients. Arthritis Rheum 56(7):2464–2466. doi:10.1002/art.22735 PubMedCrossRefGoogle Scholar
  12. 12.
    Enestrom S, Bengtsson A, Frodin T (1997) Dermal IgG deposits and increase of mast cells in patients with fibromyalgia—relevant findings or epiphenomena? Scand J Rheumatol 26(4):308–313PubMedCrossRefGoogle Scholar
  13. 13.
    Cordero MD, Moreno-Fernandez AM, Carmona-Lopez MI, Sanchez-Alcazar JA, Rodriguez AF, Navas P, de Miguel M (2010) Mitochondrial dysfunction in skin biopsies and blood mononuclear cells from two cases of fibromyalgia patients. Clin Biochem 43(13–14):1174–1176. doi:10.1016/j.clinbiochem.2010.06.013 PubMedCrossRefGoogle Scholar
  14. 14.
    Cordero MD, Diaz-Parrado E, Carrion AM, Alfonsi S, Sanchez-Alcazar JA, Bullon P, Battino M, de Miguel M (2013) Is inflammation a mitochondrial dysfunction-dependent event in fibromyalgia? Antioxid Redox Signal 18(7):800–807. doi:10.1089/ars.2012.4892 PubMedCentralPubMedCrossRefGoogle Scholar
  15. 15.
    Kim DH, Oh D-H, Clauw DJ (2008) Characteristic electron microscopic findings in the skin of patients with fibromyalgia–preliminary study. Clin Rheumatol 27(2):5p. doi:10.1007/s10067-007-0739-2 CrossRefGoogle Scholar
  16. 16.
    Yalcinkaya EY (2009) Skin problems in fibromyalgia. Nobel Medicus Journal 5(2):3pGoogle Scholar
  17. 17.
    Granges G, Littlejohn GO (1993) A comparative study of clinical signs in fibromyalgia/fibrositis syndrome, healthy, and exercising subjects. J Rheumatol 20(2):344–351PubMedGoogle Scholar
  18. 18.
    Thune PO (2005) The prevalence of fibromyalgia among patients with psoriasis. Acta Derm Venereol 85(1):33–37. doi:10.1080/00015550410001044 PubMedCrossRefGoogle Scholar
  19. 19.
    Grafe A, Wollina U, Tebbe B, Sprott H, Uhlemann C, Hein G (1999) Fibromyalgia in lupus erythematosus. Acta Derm Venereol 79(1):62–64PubMedCrossRefGoogle Scholar

Copyright information

© Clinical Rheumatology 2014

Authors and Affiliations

  • Valerie Laniosz
    • 1
  • David A. Wetter
    • 1
  • Desiree A. Godar
    • 1
  1. 1.Department of DermatologyMayo ClinicRochesterUSA

Personalised recommendations