Lack association of body mass index with disease activity composites of rheumatoid arthritis in Korean population: cross-sectional observation
- 229 Downloads
The debate regarding the influence of body mass index (BMI) on clinical disease activity in rheumatoid arthritis (RA) remains unsolved. This study investigates whether BMI is associated with disease activity composites and clinical parameters in Korean patients with RA. A total of 568 patients with RA were consecutively enrolled in this study. BMI and disease activity composites including the Disease Activity Score 28 (DAS28) and the Clinical/Simplified Disease Activity Index (CDAI/SDAI) were assessed. Statistical analyses were performed using Chi-square, one-way ANOVA, and multivariate regression analyses. Remission of RA disease activity was defined as ≤2.6 in a DAS28 score. The mean BMI was 22.3 kg/m2 (SD 3.1). About 60.6 % (n = 344) of enrolled patients fell into the underweight and normal BMI categories. Swollen joint count was significantly different among the four BMI categories (p = 0.038). Multivariate regression analysis showed a negative correlation of BMI and erythrocyte sediment rate (ESR) in all patients (β= − 0.011, p = 0.049) and also found that other disease activity indices were not found to be associated with BMI. In patients with remission, lower BMI was associated with higher physician global estimate (β= − 0.446, p = 0.030). The negative association between BMI and ESR in the non-remission group was noted (β= − 0.016, p = 0.019). This study revealed lack association between BMI and disease activity composites of RA, although only ESR was found to be associated with BMI in RA patients.
KeywordsBody mass index Disease activity Erythrocyte sediment rate Rheumatoid arthritis
Conflict of interest
The authors declare no competing interests.
- 8.Symmons DP, Bankhead CR, Harrison BJ, Brennan P, Barrett EM, Scott DG et al (1997) Blood transfusion, smoking, and obesity as risk factors for the development of rheumatoid arthritis: results from a primary care-based incident case–control study in Norfolk, England. Arthritis Rheum 40:1955–1961PubMedCrossRefGoogle Scholar
- 19.Steering Committee (2000) The Asia-Pacific perspective: redefining obesity and its treatment. International Diabetes Institute, MelbourneGoogle Scholar
- 20.Prevoo MLL, van't Hof MA, Kuper HH, van Leeuwen MA, van de Putte LBA, van Riel PLCM (1995) Modified disease activity scores that include twenty-eight-joint counts: Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 38:44–48PubMedCrossRefGoogle Scholar
- 21.Wells G, Becker JC, Teng J, Dougados M, Schiff M, Smolen J et al (2009) Validation of the 28-joint Disease Activity Score (DAS28) and European League Against Rheumatism response criteria based on C-reactive protein against disease progression in patients with rheumatoid arthritis, and comparison with the DAS28 based on erythrocyte sedimentation rate. Ann Rheum Dis 68:954–960PubMedCentralPubMedCrossRefGoogle Scholar
- 24.World Health Organisation (2000) Obesity: preventing and managing the global epidemic. Report of a WHO Consultation. World Health Organ Tech Rep Ser 894:i–xii, 1–253Google Scholar
- 27.Sim KW, Lee SH, Lee HS (2001) The relationship between body mass index and morbidity in Korea. Korean J Obes 10:14–55Google Scholar
- 29.Guin A, Chatterjee Adhikari M, Chakraborty S, Sinhamahapatra P, Ghosh A (2013) Effects of disease modifying anti-rheumatic drugs on subclinical atherosclerosis and endothelial dysfunction which has been detected in early rheumatoid arthritis: 1-year follow-up study. Semin Arthritis Rheum 43:48–54PubMedCrossRefGoogle Scholar