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Clinical Rheumatology

, Volume 32, Issue 11, pp 1673–1675 | Cite as

Leflunomide, a valid and safe drug for the treatment of chronic anterior uveitis associated with juvenile idiopathic arthritis

  • Clara MolinaEmail author
  • Consuelo Modesto
  • Nieves Martín-Begué
  • Cristina Arnal
Brief Report

Introduction

Chronic anterior uveitis (CAU) is an important extra-articular manifestation of juvenile idiopathic arthritis (JIA).

Although the incidence of serious sight loss varies between series (6–25 %), CAU related to JIA (CAUJIA) is an important cause of blindness in children from developed countries [1, 2]. The severity of the complications obliges the use of prompt, aggressive treatment to prevent sequelae. In an attempt to spare glucocorticoids and avoid side effects, various immunosuppressive drugs have been used. Leflunomide (LFN) has proven to be safe and effective long-term therapy for the articular component of JIA [3]. To our knowledge, there is no available information about the efficacy of LFN in CAUJIA.

Materials and methods

A retrospective, observational study was performed to evaluate the efficacy and safety of LFN in the treatment of CAUJIA. Thirteen patients with CAU from our cohort of 417 children with JIA, all of whom had received LFN for at least 7 months to...

Keywords

Juvenile Idiopathic Arthritis Uveitis Leflunomide Juvenile Idiopathic Arthritis Patient Severe Vision Loss 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Disclosures

The authors have not received financial support or any other benefits from commercial sources for the work reported in the manuscript. The authors declare no conflicts of interest with regard to the work (Clara Molina, none; Consuelo Modesto, none; Nieves Martín-Begué, none; and Cristina Arnal, none).

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Copyright information

© Clinical Rheumatology 2013

Authors and Affiliations

  • Clara Molina
    • 1
    Email author
  • Consuelo Modesto
    • 2
  • Nieves Martín-Begué
    • 3
  • Cristina Arnal
    • 2
  1. 1.Rheumatology DepartmentHospital Universitario y Policlínico La FeValenciaSpain
  2. 2.Rheumatology DepartmentHospital Universitario Vall HebronBarcelonaSpain
  3. 3.Ophthalmology DepartmentHospital Universitario Vall HebronBarcelonaSpain

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