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Clinical Rheumatology

, Volume 32, Issue 10, pp 1451–1458 | Cite as

Abatacept and its use in the treatment of rheumatoid arthritis (RA) in the Czech Republic—data from the ATTRA registry

  • Pavel Horák
  • Martina Skácelová
  • Karel Hejduk
  • Andrea Smržová
  • Karel Pavelka
Original Article

Abstract

The Czech national registry ATTRA collects data from patients with rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, and juvenile idiopathic arthritis, treated with the biologic drugs. ATTRA is a prospective centralized computerized registry of patients with a focus on efficacy, safety, and quality of life data. Abatacept is approved as a second-line agent which can be prescribed after a failure of at least one TNF-alfa inhibitor. Data of patients treated with abatacept has been collected since 2008. A statistical analysis of the group of RA patients treated with abatacept was performed recently. ATTRA registered 162 patients with RA treated with abatacept, the mean age 51.0 ± 12.2 (median 53.1, 19–74 years), the mean duration of the disease was 14 ± 9.1, median 11.3 years (0–41). One hundred thirty patients (80.2 %) were female. The mean DAS28 was at week 0, 5.9 ± 1.1, at week 16, 4.1 ± 1.4, at week 24, 3.8 ± 1.2, at week 36, 3.6 ± 1.3, and at week 52, 3.5 ± 1.2. DAS28 remission was achieved at week 16 in 15.8 %, at week 24 in 10 %, at week 36 in 20.9 %, and at week 52 in 20.8 % of patients. Of those patients with a DAS28 <2.6 (remission) at week 16, 58.3 % remained in remission at the week 52. Of those patients with DAS28 >5.1 (high disease activity) at the week 16, only 41.7 % had DAS >5.1 at week 52. One year on treatment survival was 82 %. Altogether 50 non-serious adverse events (AE) were reported in 36 patients (22 %) and 11 serious AE in 10 patients (6 %) with the most common being infections (31) and skin rashes (5). Just one non-serious allergic reaction was reported. Data from the ATTRA registry confirms a good overall efficacy and safety profile and a very good on drug survival with abatacept.

Keywords

Abatacept Registry Rheumatoid arthritis 

Notes

Acknowledgement

The authors would like to acknowledge all cooperating centers of ATTRA registry: Prof. Karel Pavelka, Institute of Rheumatology in Prague; Marie Sedláčková, MD, Department of Rheumatology, Thomayer Faculty Hospital in Prague; Hana Brabcová, MD, Department of Rheumatology, Faculty Hospital in Plzeň; Prof. Pavel Horák, III, Department of Internal Medicine-Nephrology, Rheumatology, Endocrinology, Palacky University of Olomouc; Ladislav Bortlík, MD, ARTROSCAN, Ostrava; Associate Prof. Petr Bradna, II, Department of Internal Medicine, Faculty Hospital in Hradec Králové; Ivana Součková, MD, Department of Rheumatology, Regional Hospital in Liberec; Zdeněk Fojtík, MD, Department of Rheumatology, Faculty Hospital of Brno; Sevda Augustinová, MD, Medipoint PLUS, České Budějovice; Petr Vítek, MD, PV—Medical, Zlín; Alena Tichá, MD, Rheumatology Clinic Sokolov; Dagmar Galatíková, MD, Rheumatology Clinic Bruntál; Helena Šedivá, MD, Rheumatology Clinic, Ústí nad Labem; Olga Janušková, MD, Rheumatology Clinic, Kroměříž; Eva Dokoupilová, MD, Rheumatology Clinic, Uherské Hradiště; Associate Prof. Petr Němec, Internal Department Rheumatology Clinic, Faculty Hospital Svatá Anna, Brno; Vlastimil Novotný, MD, Rheumatology Clinic, Mariánské Lázně ; Julius Vachtenheim, MD, Rheumatology Clinic Jihlava; Pavla Vavřincová, MD, Rheumatology Clinic, Faculty Hospital Motol, Prague; Klára Šírová, MD, Rheumatology Clinic, Ostrava; Vít Kuba, MD, Rheumatology Clinic Chomutov; Associate Prof. Josef Hoza, Children Hospital Faculty Hospital in Prague; Iva Kielkowská, MD, Faculty Hospital, Ostrava; Zdeněk Dvořák, MD, ARTHROMED, Pardubice; Marie Macků, MD, Children Department , Faculty Hospital, Brno; Jana Korbielová, MD, REDIAMB Havířov; Libor Novosad, MD, L.K.N. Arthrocentrum, Hlučín; Jana Kopačková, MD, ARTMEDI UPD, Hostivice. This study was funded by ATTRA registry, Czech Republic

Disclosures

None.

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Copyright information

© Clinical Rheumatology 2013

Authors and Affiliations

  • Pavel Horák
    • 1
  • Martina Skácelová
    • 1
  • Karel Hejduk
    • 2
  • Andrea Smržová
    • 1
  • Karel Pavelka
    • 3
  1. 1.Department of Internal Medicine III—Nephrology, Rheumatology, Endocrinology, Faculty of Medicine and DentistryPalacký University in Olomouc, University Hospital OlomoucOlomoucCzech Republic
  2. 2.Institute of Biostatistics and AnalysesMasaryk UniversityBrnoCzech Republic
  3. 3.Institute of Rheumatology, 1st Medical FacultyCharles University in PraguePragueCzech Republic

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