Clinical Rheumatology

, Volume 32, Issue 9, pp 1301–1307 | Cite as

Human papillomavirus vaccine and systemic lupus erythematosus

  • Mariele Gatto
  • Nancy Agmon-Levin
  • Alessandra Soriano
  • Raffaele Manna
  • Ramit Maoz-Segal
  • Shaye Kivity
  • Andrea Doria
  • Yehuda ShoenfeldEmail author
Original Article


To investigate the association between human papillomavirus (HPV) vaccination and autoimmune manifestations compatible with systemic lupus erythematosus (SLE) or SLE-like disease, the medical history of six women who presented with SLE or SLE-like disease following HPV immunization was collected. Data regarding type of vaccine, number of immunization, family and personal, clinical and serological features, as well as response to treatments were analyzed. In the reported cases, several common features were observed, such as personal or familial susceptibility to autoimmunity or adverse response to a prior dose of the vaccine, both of which may be associated with a higher risk of post-vaccination autoimmunity. Favorable response to immunosuppressant was observed in all patients. In the current study, a temporal association between immunization with HPV vaccine and the appearance of a spectrum of SLE-like conditions is reported. Additionally, among the patients described, several common features were observed that may enable better identification of subjects at risk. Further studies are required to assess the safety of immunization with the HPV vaccine in patients with autoimmune-rheumatic diseases or in subject at risk of autoimmunity as well as the potential beneficial effect of preventive immunosuppressants.


Anti-phospholipids antibodies ASIA Autoimmunity Human papillomavirus Systemic lupus erythematosus Vaccine 



YS appears in court defending subjects afflicted by immunization. All other authors: disclosure: none.


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Copyright information

© Clinical Rheumatology 2013

Authors and Affiliations

  • Mariele Gatto
    • 1
  • Nancy Agmon-Levin
    • 2
    • 3
  • Alessandra Soriano
    • 4
  • Raffaele Manna
    • 4
  • Ramit Maoz-Segal
    • 2
  • Shaye Kivity
    • 2
    • 3
    • 5
  • Andrea Doria
    • 1
  • Yehuda Shoenfeld
    • 2
    • 3
    • 6
    Email author
  1. 1.Department of MedicineUniversity of PadovaPadovaItaly
  2. 2.The Zabludowicz Center for Autoimmune DiseasesSheba Medical CenterTel HashomerIsrael
  3. 3.Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael
  4. 4.Periodic Fever Research CentreCatholic University of Sacred HeartRomeItaly
  5. 5.Rheumatic Disease UnitSheba Medical CenterTel HashomerIsrael
  6. 6.Sackler Faculty of Medicine, Incumbent of the Laura Schwarz-Kip Chair for Research of Autoimmune DiseasesTel Aviv UniversityTel AvivIsrael

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