Clinical Rheumatology

, Volume 32, Issue 3, pp 395–398 | Cite as

Limitations of a single-point evaluation of anti-MDA5 antibody, ferritin, and IL-18 in predicting the prognosis of interstitial lung disease with anti-MDA5 antibody-positive dermatomyositis

  • Yoshinao MuroEmail author
  • Kazumitsu Sugiura
  • Masashi Akiyama
Brief Report


Autoantibodies against melanoma differentiation-associated gene 5 (MDA5) are important serological markers in dermatomyositis (DM) with rapidly progressive interstitial lung disease (ILD). Recent studies noted that anti-MDA5 antibody (anti-MDA5ab), ferritin, and IL-18 are useful biomarkers for evaluating the responses to treatment and the status of ILD in anti-MDA5ab-positive DM. In this study, we further studied the importance of anti-MDA5ab levels and of ferritin and IL-18 concentrations in our patients. These biomarkers could be sometimes useful for evaluating ILD status and/or predicting the prognosis in patients with anti-MDA5ab-positive DM with several exceptional cases. A single-point evaluation of anti-MDA5ab levels and of ferritin and IL-18 concentrations has limitations in predicting the prognosis of ILD with DM. We consider that the timing of initial therapy and the anti-MDA5ab isotype, in addition to the patient’s age, are also crucial factors for predicting the prognosis.


Anti-MDA5 antibody Dermatomyositis Ferritin IL-18 Interstitial lung disease 



This work was supported by grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan (23591618 to YM and 23249058 to MA) and by a grant from the Ministry of Health, Labour and Welfare of Japan (to YM).




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Copyright information

© Clinical Rheumatology 2012

Authors and Affiliations

  • Yoshinao Muro
    • 1
    Email author
  • Kazumitsu Sugiura
    • 1
  • Masashi Akiyama
    • 1
  1. 1.Division of Connective Tissue Disease and Autoimmunity, Department of DermatologyNagoya University Graduate School of MedicineNagoyaJapan

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