Clinical Rheumatology

, Volume 31, Issue 10, pp 1449–1454

Association of FCRL4 polymorphisms on disease susceptibility and severity of ankylosing spondylitis in Chinese Han population

  • Zhen Zeng
  • Zhenhua Duan
  • Tianchen Zhang
  • Sheng Wang
  • Guixing Li
  • Yang Mei
  • Jing Gao
  • Rui Ge
  • Dongqing Ye
  • Yanfeng Zou
  • Shengqian Xu
  • Jianhua Xu
  • Li Zhang
  • Faming Pan
Original Article

DOI: 10.1007/s10067-012-2028-y

Cite this article as:
Zeng, Z., Duan, Z., Zhang, T. et al. Clin Rheumatol (2012) 31: 1449. doi:10.1007/s10067-012-2028-y

Abstract

Previous studies have found that the Fc receptor-like (FCRL) molecule, involved in controlling B cell signaling, may contribute to the autoimmune disease process. Many studies have reported the relation of FCRL gene family with SLE and RA. We hypothesized that FCRL4 may be a key gene for ankylosing spondylitis (AS) development. To test this hypothesis, we screened FCRL4 polymorphisms in the Chinese Han population. Five tag single nucleotide polymorphisms (SNPs), including rs14335, rs849826, rs10489674, rs2778003, and rs2777963, were selected. Using a case–control study, five tag SNPs, which captured the majority of known common variation within FCRL4 gene, were selected and genotyped by Multiplex Snapshot technique. We analyzed 299 patients and 300 controls from China. The genotype analysis demonstrated that one of the FCRL4 tag SNPs rs2777963 TT genotype may be a risk factor of AS (χ2 = 7.374, p = 0.024). The haplotype analysis indicated that there were no significant differences between AS cases and controls. Patients with AS who had rs14335 AA genotype had a significantly declined visual analogue scale patient's global assessment scores compared to those with the GG genotype (31.21 ± 26.25 vs 40.54 ± 25.40, p = 0.035) and GA genotype (38.29 ± 24.94 vs 40.54 ± 25.40, p = 0.044), and in locus rs10489674, TT genotype had significantly increased Bath Ankylosing Spondylitis Disease Activity Index scores compared to those with the CC genotype (4.73 ± 2.43 vs 3.15 ± 1.61, p = 0.003) and CT genotype (4.73 ± 2.43 vs 2.97 ± 1.71, p = 0.001). The FCRL4 polymorphisms may play an important role in the susceptibility and severity of AS in the Chinese Han population.

Keywords

Ankylosing spondylitis Bath Ankylosing Spondylitis Disease Activity Index Fc receptor-like4 gene Single nucleotide polymorphisms 

Copyright information

© Clinical Rheumatology 2012

Authors and Affiliations

  • Zhen Zeng
    • 1
  • Zhenhua Duan
    • 1
  • Tianchen Zhang
    • 1
  • Sheng Wang
    • 1
  • Guixing Li
    • 1
  • Yang Mei
    • 1
  • Jing Gao
    • 1
  • Rui Ge
    • 1
  • Dongqing Ye
    • 1
  • Yanfeng Zou
    • 1
  • Shengqian Xu
    • 2
  • Jianhua Xu
    • 2
  • Li Zhang
    • 3
  • Faming Pan
    • 1
  1. 1.Department of Epidemiology and Biostatistics, School of Public HealthAnhui Medical UniversityHefeiChina
  2. 2.Department of Rheumatism and Immunitythe First Affiliated Hospital of Anhui Medical UniversityHefeiChina
  3. 3.Anhui Medical Genetics CenterAnhui Medical CollegeHefeiChina

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