Although involvement of the reticuloendothelial system in systemic lupus erythematosus (SLE) is a well-recognised concomitant of the disease, spontaneous splenic rupture is an unusual occurrence. We observed a 54-year-old woman with SLE who had spontaneous splenic rupture during the late course of the disease and showed some changes histopathologically. The courses and the clinical characteristics of such patients are reviewed, and the diagnosis and treatment of these cases are discussed. Early evaluation for SLE patients with spontaneous splenic rupture should be considered and included in the differential diagnosis of acute abdomen, as it may affect follow-up and treatment, although the condition is rare.
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This work was partly funded by a Research Grant for Health Science and Technology development and innovation of Pudong New Area of Shanghai (Grant No. PKJ2011-Y06).
The authors thank Prof. SongGuo Zheng for his review of the manuscript and his insightful comments.
Vallabhaneni S, Scott H, Carter J, Treseler P, Machtinger EL (2011) Atraumatic splenic rupture: an unusual manifestation of acute HIV infection. AIDS Patient Care and STDs 25(8):461–464PubMedCrossRefGoogle Scholar
Hoar FJ, Chan SY, Stonelake PS, Wolverson RW, Bareford D (2003) Splenic rupture as a consequence of dual malignant pathology: a case report. J Clin Pathol 56:709–710PubMedCrossRefGoogle Scholar
Fishman D, Isenberg DA (1997) Splenicinvolvement in rheumatic diseases. Sem Arthrit Rheum 27:141–155CrossRefGoogle Scholar
Zimmerman-Gorska I, Bielaka K (1971) Splenic rupture in the course of SLE. Pol Tyg Lek 26:1991–1992Google Scholar
Krauser R (1976) Spontaneous rupture of the spleen in systemic lupus erythematosus. JAMA 236:P1149CrossRefGoogle Scholar
Cheng-Chung W, Lan J, Liu T (1985) Systemic lupus erythematosus with spontaneous rupture of the spleen. Formosan Med Assoc 84:1186–1990Google Scholar
Tolaymat A, Mousily FA, Haafiz AB, Lammert N, Afshari S (1995) Spontaneous rupture of the spleen in a patient with systemic lupus erythematosus. J Rheumatol 22:2344–2345PubMedGoogle Scholar
Karassa FB, Isenberg DA (2001) Spontaneou rupture of the spleen an unusual complication of systemic lupus erythematosus. Lupus 10:876–878PubMedCrossRefGoogle Scholar
Renzulli P, Hostettler A, Schoepfer AM, Gloor B, Candinas D (2009) Systematic review of atraumatic splenic rupture. Br J Surg 96:1114–1121PubMedCrossRefGoogle Scholar
Nicholl J, McAdam G, Donaldson D (1993) Three cases of early spontaneous splenic rupture associated with acute viral infection. J R Coll Surg Edinb 38:351–360PubMedGoogle Scholar
Burst M, Power R, Keely S, Matthews NT (1991) Severe meningococcal septicemia associated with splenic rupture. Med J Aust 155:713–714Google Scholar