Clinical Rheumatology

, Volume 31, Issue 3, pp 469–477 | Cite as

Effects of intravenous iron saccharate on improving severe anemia in rheumatoid arthritis patients

  • Wei-Sheng Chen
  • Chun-Yu Liu
  • Hui-Ting Lee
  • Kelvin Tsai
  • Yi-Chun Lin
  • Der-Cherng Tarng
  • Chao-Hung Ho
  • Hsiao-Yi Lin
Original Article


Anemia in rheumatoid arthritis (RA) is multifactorial. Iron deficiency, either definite or relative (defect in iron utilization), exists in RA patients with anemia. Intravenous iron therapy is indicated in severe and symptomatic cases or those with conditions precluding use of oral iron, but its safety and long-term efficacy have not been well-established. Forty severe anemic (hemoglobin < 9 g/dL) RA patients with or without demonstrable bone marrow iron stain were enrolled in this study. Fractionated administration of intravenous iron saccharate was undertaken and the median follow-up time was 1 year. All patients exhibited significant elevations of hemoglobin 3 months after treatment, which were more pronounced in the nonstainable iron marrow subjects {median (interquartile range): 3.8 (2.9–4.8) g/dL versus 2.9 (2.0–3.0) g/dL, p < 0.01}. Thereafter, hemoglobin remained at a plateau level that lasted during the observation period. Throughout the whole course, none of the cases exhibited side effects or flare up of disease activities. The use of intravenous iron saccharate, preferably administrated in a fractionated way, is effective in the correction of severe anemia in RA patients, especially those with nonstainable iron marrow.


Anemia Iron compounds Rheumatoid arthritis 





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Copyright information

© Clinical Rheumatology 2011

Authors and Affiliations

  • Wei-Sheng Chen
    • 1
    • 4
    • 6
  • Chun-Yu Liu
    • 2
    • 4
    • 7
  • Hui-Ting Lee
    • 4
    • 5
    • 6
  • Kelvin Tsai
    • 3
  • Yi-Chun Lin
    • 1
  • Der-Cherng Tarng
    • 1
    • 4
    • 6
  • Chao-Hung Ho
    • 2
  • Hsiao-Yi Lin
    • 1
    • 4
    • 8
  1. 1.Division of Allergy, Immunology and RheumatologyTaipei Veterans General HospitalTaipeiRepublic of China
  2. 2.Division of Oncology and HematologyTaipei Veterans General HospitalTaipeiRepublic of China
  3. 3.Division of Nephrology, Department of MedicineTaipei Veterans General HospitalTaipeiRepublic of China
  4. 4.National Yang Ming University School of MedicineTaipeiRepublic of China
  5. 5.Division of Allergy, Immunology and RheumatologyWan-Fang HospitalTaipeiRepublic of China
  6. 6.Institute of Clinical MedicineNational Yang Ming UniversityTaipeiRepublic of China
  7. 7.Institute of Biopharmaceutical SciencesNational Yang Ming UniversityTaipeiRepublic of China
  8. 8.Section of Allergy, Immunology and Rheumatology, Department of MedicineVeterans General HospitalTaipeiRepublic of China

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