Clinical Rheumatology

, Volume 30, Issue 12, pp 1595–1601 | Cite as

Survival analysis of patients with dermatomyositis and polymyositis

Analysis of 192 Chinese cases
  • Kuang-Hui Yu
  • Yeong-Jian Jan Wu
  • Chang-Fu Kuo
  • Lai-Chu See
  • Yu-Ming Shen
  • Hsiao-Chun Chang
  • Shue-Fen Luo
  • Huei-Huang Ho
  • I-Jung Chen
Original Article


To estimate the mortality rate and identify factors predicting survival in patients with polymyositis (PM) and dermatomyositis (DM). The medical records of 192 PM/DM patients who were treated at Chang Gung Memorial Hospital from 1999 through 2008 were retrospectively reviewed. The Taiwan National Death Registry (1999–2008) was used to obtain their survival status. Thirty-one (16.1%) of the 192 patients with PM/DM had an associated malignancy; 41 (21.4%) had interstitial lung disease (ILD). During the follow-up period, 55 (28.6%) patients died and the overall cumulative survival rate was 79.3% at 1 year, 75.7% at 2 years, 69.9% at 5 years, and 66.2% at 10 years. In univariate analysis, older age at PM/DM onset, anemia, thrombocytopenia, leukopenia, diabetes mellitus, ILD, cancer, and non-use of azathioprine were associated with higher mortality (p = 0.0172, 0.0484, <0.0001, 0.0008, 0.0001, 0.0036, 0.0010, and 0.0019, respectively). In multivariate Cox regression analysis, thrombocytopenia (hazard ratio [HR] 4.94, 95% confidence interval [CI] 2.60–9.37, p < 0.0001), diabetes mellitus (HR 2.57, 95% CI 1.38–4.80, p < 0.0001), cancer (HR 2.30, 95% CI 1.26–4.22, p = 0.0030), and ILD (HR 1.98, 95% CI 1.11–3.51, p = 0.0182) were positively associated with mortality. Use of azathioprine (HR 0.35, 95% CI 0.16–0.74, p = 0.0064) was negatively associated with mortality. This study confirmed the high mortality rate (28.6%) in PM/DM patients. Survival time was significantly reduced in patients with thrombocytopenia, diabetes mellitus, ILD, and cancer patients than in those without these conditions.


Dermatomyositis Polymyositis Prognosis Survival analysis 



The authors are grateful to Chang Gung Memorial Hospital (Project No. CMRPG390211) and the Ministry of Education of Taiwan (Project No. EMRPD180201) for financially supporting this research. This study is based in part on data from the National Health Insurance Research Database provided by the Bureau of National Health Insurance, Department of Health and managed by National Health Research Institutes (Registered number 99067). The interpretation and conclusions contained herein do not represent those of Bureau of National Health Insurance, Department of Health or National Health Research Institutes.




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Copyright information

© Clinical Rheumatology 2011

Authors and Affiliations

  • Kuang-Hui Yu
    • 1
    • 2
  • Yeong-Jian Jan Wu
    • 1
    • 2
  • Chang-Fu Kuo
    • 1
    • 2
  • Lai-Chu See
    • 3
  • Yu-Ming Shen
    • 4
  • Hsiao-Chun Chang
    • 1
  • Shue-Fen Luo
    • 1
    • 2
  • Huei-Huang Ho
    • 1
    • 2
  • I-Jung Chen
    • 2
    • 5
  1. 1.Division of Allergy, Immunology and RheumatologyChang Gung Memorial HospitalTao-YuanTaiwan
  2. 2.Chang Gung UniversityTao-YuanTaiwan
  3. 3.Department of Public HealthCollege of Medicine, and Biostatistics Core Laboratory, Molecular Medicine Research Center, Chang Gung UniversityTao-YuanTaiwan
  4. 4.Biostatistics Consulting Center, Department of Public HealthChang Gung UniversityTao-YuanTaiwan
  5. 5.School of MedicineChang Gung UniversityTao-YuanTaiwan

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