Effective treatment of Kimura’s disease with leflunomide in combination with glucocorticoids
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Kimura’s disease (KD) is a rare, benign, chronic inflammatory disease which typically presents as persisting or recurring tumor-like lesions in the head and neck area that can be easily misdiagnosed. We report one patient with KD treated with leflunomide in combination with glucocorticoids and analyzed the literature on treatment of KD. The patient had a recurrent mass in the left upper arm with eosinophilia and elevated serum IgE but no renal involvement. The clinical manifestations improved markedly within 1 month, and blood eosinophil count and serum IgE normalized. Corticosteroids were then tapered gradually without recurrence or severe side effects in the 2-year follow-up period. Literature analysis identified four different non-drug interventions and 18 different drugs for treating KD, most of which were obtained from case reports. Our use of combination therapy of leflunomide and glucocorticoids suggests the need for a controlled trial for the treatment of this rare disorder.
KeywordsEosinophilia Kimura’s disease Leflunomide Lymphadenopathy
We gratefully thank the cooperation of the KD patient reported here, as well as the members of the medical staff and pathologist who generously collaborated with this study.
- 27.Beccastrini E, Emmi G, Chiodi M, et al (2010) Kimura's disease: case report of an Italian young male and response to oral cyclosporine A in an 8 years follow-up. Clin Rheumatol Apr 19 [Epub ahead of print]Google Scholar
- 47.Bartlett RR, Mattar T, Weithmann U et al (1989) Leflunomide (HWA 486): a novel immunorestoring drug. In: Therapeutic approaches to inflammatory diseases. Amsterdam, Elsevier North-Holland, pp 215–228Google Scholar