Clinical Rheumatology

, Volume 30, Issue 3, pp 429–432 | Cite as

A case of antisynthetase syndrome in a rheumatoid arthritis patient with anti-PL-12 antibody following treatment with etanercept

  • Yuki Ishikawa
  • Naoichiro YukawaEmail author
  • Daisuke Kawabata
  • Koichiro Ohmura
  • Takao Fujii
  • Takashi Usui
  • Tsuneyo Mimori
Case Based Review


In our earlier study, we had reported the case of a patient with rheumatoid arthritis (RA), who had anti-Jo-1 antibodies. This patient had received etanercept (ETN) therapy for RA, after which she had developed overt polymyositis (PM). Although various autoimmune phenomena, including lupus-like diseases, vasculitides, or psoriatic skin lesions, are associated with antitumor necrosis factor (TNF) therapy, the development of PM/dermatomyositis (DM) or antisynthetase syndrome following anti-TNF therapy is extremely rare. Here, we report a case of an RA patient with anti-PL-12 antibodies, who received ETN therapy and subsequently developed the antisynthetase syndrome. She recovered when ETN therapy was withdrawn and high-dose corticosteroid was administered. To date, there have been only five reported cases of RA patients with anti-Jo-1 antibodies who developed overt PM/DM following anti-TNF therapy and only one case of antisynthetase syndrome in an RA patient with anti-PL-7 antibodies. Our patients and the abovementioned reports strongly suggest that onset of overt PM/DM or antisynthetase syndrome in RA patients with anti-aminoacyl tRNA synthetase antibodies is associated with anti-TNF therapy.


Adverse drug effect Anti-ARS antibodies Anti-TNF therapy Polymyositis/dermatomyositis 





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Copyright information

© Clinical Rheumatology 2011

Authors and Affiliations

  • Yuki Ishikawa
    • 1
  • Naoichiro Yukawa
    • 1
    Email author
  • Daisuke Kawabata
    • 1
  • Koichiro Ohmura
    • 1
  • Takao Fujii
    • 1
  • Takashi Usui
    • 1
  • Tsuneyo Mimori
    • 1
  1. 1.Department of Rheumatology and Clinical ImmunologyKyoto University HospitalKyotoJapan

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