Clinical Rheumatology

, Volume 30, Issue 5, pp 703–706 | Cite as

Takayasu’s arteritis progression on anti-TNF biologics: a case series

  • Mohammed Osman
  • Stephen Aaron
  • Michelle Noga
  • Elaine Yacyshyn
Brief Report


Takayasu’s arteritis (TA) is a rare granulomatous vasculitic disease that affects the aorta and its major branches. Recent studies have suggested that anti-TNFα biological therapies are highly effective in treating TA refractory to conventional immunosuppressive therapy. We describe two patients with TA: one with progressive TA despite management with two different anti-TNFα agents, infliximab and adalimumab, and another who developed TA while treated with infliximab for the management of pre-existing Crohn’s disease. From our observations, we believe that a multicentered randomized study should be designed to assess the extent of resistance to these agents when different therapeutic doses are employed for managing TA.


Anti-TNF biologics Crohn’s disease Infliximab Takayasu’s arteritis 





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Copyright information

© Clinical Rheumatology 2011

Authors and Affiliations

  • Mohammed Osman
    • 1
  • Stephen Aaron
    • 1
  • Michelle Noga
    • 2
  • Elaine Yacyshyn
    • 1
  1. 1.Division of Rheumatology, Department of Medicine562 HMRC University of AlbertaEdmontonCanada
  2. 2.Department of Radiology and Diagnostic ImagingUniversity of AlbertaEdmontonCanada

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