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Clinical Rheumatology

, Volume 30, Issue 2, pp 179–184 | Cite as

Interleukin-6 gene polymorphism in Iranian patients with systemic lupus erythematosus

  • Esmaeil Moazemi Godarzi
  • Eskandar Kamali Sarvestani
  • Elham Aflaki
  • Zahra Amirghofran
Original Article

Abstract

Interleukin 6 (IL-6) has been shown to be related to the pathogenesis of systemic lupus erythematosus (SLE). In the present study, the relationship between two polymorphisms in the promoter region of IL-6 gene at positions −572 G/C and −174 G/C and disease susceptibility in 401 Iranian patients with SLE was investigated using polymerase chain reaction–restriction fragment length polymorphism method. The genotype distribution and allele frequencies of IL-6 gene polymorphism at −174 position showed no significant difference between SLE patients and controls. In contrary, both allelic and genotypic frequencies at the −572 position significantly differed in SLE patients and controls. At this position, GG genotype was observed in 77.9% of patients compared to 68.9% in the control group (p < 0.014). The frequency of −572 G allele in patients (87.3%) was also higher than in controls (83.2%; p = 0.034). The haplotype study showed no significant difference between patients and healthy subjects. Study of the relationship between these polymorphisms and clinical manifestations and laboratory parameters showed an association between −174 polymorphism and the presence of antinuclear antibodies in all patients and rash and hematuria in male patients (p < 0.04). At −572 polymorphism, a significant difference with regard to photosensitivity in male patients (p = 0.04) was found. In conclusion, results of this study showed that −572 polymorphism plays an important role in susceptibility to SLE and that −174 polymorphism could influence the presence of antinuclear antibodies in the patients.

Keywords

IL-6 gene polymorphism Systemic lupus erythematosus 

Notes

Acknowledgment

This work was supported by grant no. 2929 from Shiraz University of Medical Sciences.

Disclosures

None

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Copyright information

© Clinical Rheumatology 2010

Authors and Affiliations

  • Esmaeil Moazemi Godarzi
    • 1
  • Eskandar Kamali Sarvestani
    • 1
    • 2
  • Elham Aflaki
    • 2
    • 3
  • Zahra Amirghofran
    • 1
    • 2
    • 4
  1. 1.Immunology Department, Medical SchoolShiraz University of Medical SciencesShirazIran
  2. 2.Autoimmune Disease Research CenterShiraz University of Medical SciencesShirazIran
  3. 3.Department of Internal medicineShiraz University of Medical SciencesShirazIran
  4. 4.Medicinal and Natural Products Chemistry Research CenterShiraz University of Medical SciencesShirazIran

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