Clinical Rheumatology

, Volume 32, Supplement 1, pp 43–45

Hormonal therapy in a patient with ovarian agenesis and possible SLE: a choice to be made

  • Roni Idan
  • Steven D. Hajdu
  • Nancy Agmon-Levin
  • Yehuda Shoenfeld
Case Report

DOI: 10.1007/s10067-010-1437-z

Cite this article as:
Idan, R., Hajdu, S.D., Agmon-Levin, N. et al. Clin Rheumatol (2013) 32(Suppl 1): 43. doi:10.1007/s10067-010-1437-z

Abstract

Systemic lupus erythromatosus (SLE) is an autoimmune disease, which affects mainly women in the reproductive age and is influenced by hormonal changes. Therefore, hormone supplementation for patients with SLE either as contraceptives or as postmenopausal supplementation remains a controversial issue. Herein, we report a case of a 22-year-old woman with a history of ovarian agenesis, treated for several years with hormone therapy in order to reduce the risk of osteoporosis and other estrogen-deficient disorders. At the current evaluation, she met 3 of 11 diagnostic criteria for SLE along with a strong familial autoimmune predisposition. Precipitation of SLE in patients treated with hormonal therapy has been previously described. This prompted us to seek alternative drug therapies that prevent both the onset of overt SLE as well as the progression of estrogen-deficient phenomena. This unique case illustrates the dilemma of using hormone therapy in patients at risk to develop SLE and the current therapeutic alternatives.

Keywords

Hormone therapy Osteoporosis Ovarian agenesis SLE Vitamin D 

Copyright information

© Clinical Rheumatology 2010

Authors and Affiliations

  • Roni Idan
    • 1
  • Steven D. Hajdu
    • 1
  • Nancy Agmon-Levin
    • 1
  • Yehuda Shoenfeld
    • 1
    • 2
    • 3
  1. 1.The Zabludowicz Center for Autoimmune Diseases and Department of Medicine BSheba Medical CenterTel-AvivIsrael
  2. 2.Incumbent of the Laura Schwarz-Kip Chair for Research of Autoimmune DiseasesTel-Aviv UniversityTel-AvivIsrael
  3. 3.Department of Medicine B and Center for Autoimmune DiseasesChaim Sheba Medical CenterTel HashomerIsrael

Personalised recommendations