Clinical Rheumatology

, Volume 29, Issue 7, pp 815–818 | Cite as

Renal cortical necrosis at presentation in a patient with systemic lupus erythematosus: an autopsy case report

  • Megha S. Uppin
  • Liza Rajasekhar
  • H. Swetha
  • V. R. Srinivasan
  • Aruna K. Prayaga
Case Report


Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disorder. Renal involvement has the worst prognosis. However, renal cortical necrosis is extremely unusual in SLE. In this case report, we describe the autopsy findings in a young female patient with SLE presenting with renal failure. At autopsy, there was Libmann–Sacks endocarditis with multiorgan infarcts and renal cortical necrosis. Secondary antiphospholipid antibodies contribute to the cardiac and renal manifestations in SLE. We discuss the incidence and pathogenesis of endocarditis with differential diagnosis for cortical necrosis in a patient of SLE.


CAPS Renal cortical necrosis SLE 





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Copyright information

© Clinical Rheumatology 2010

Authors and Affiliations

  • Megha S. Uppin
    • 1
  • Liza Rajasekhar
    • 2
  • H. Swetha
    • 1
  • V. R. Srinivasan
    • 3
  • Aruna K. Prayaga
    • 1
  1. 1.Department of PathologyNizam’s Institute of Medical SciencesHyderabadIndia
  2. 2.Department of RheumatologyNizam’s Institute of Medical SciencesHyderabadIndia
  3. 3.Department of General MedicineNizam’s Institute of Medical SciencesHyderabadIndia

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