Clinical Rheumatology

, Volume 28, Issue 9, pp 1079–1082 | Cite as

Patients treated by tegaserod for irritable bowel syndrome with constipation showed significant improvement in fibromyalgia symptoms. A pilot study

  • Tatiana Reitblat
  • Doron Zamir
  • Ilia Polishchuck
  • Galina Novochatko
  • Stephen Malnick
  • Leonid Kalichman
Brief Report


The symptoms of irritable bowel syndrome (IBS) are commonly seen in fibromyalgia (FM) patients. This study aimed to evaluate the effect of 5-hydroxytryptamin-4 receptor partial agonist (tegaserod) on the symptoms of FM among the patients who receive the medicine because of IBS. Forty-one female patients with IBS and constipation, which were subjects to tegaserod treatment, were examined by rheumatologist and 14 were found to suffer from FM. The fibromyalgia impact questionnaire (FIQ) and clinical examination were done before tegaserod treatment and 1 month after. The IBS status, the total FIQ score, the number of tender points and pain in tender points were lowered significantly after the treatment (p < 0.001 for all variables). The results of this pilot study provide the preliminary evidence that FM patients can benefit from treatment by 5-hydroxytryptamin-4 receptor partial agonist. Additional studies are needed to support this conclusion.


Comorbidity Fibromyalgia Irritable bowel syndrome Tegaserod 


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Copyright information

© Clinical Rheumatology 2009

Authors and Affiliations

  • Tatiana Reitblat
    • 1
  • Doron Zamir
    • 2
    • 3
  • Ilia Polishchuck
    • 2
  • Galina Novochatko
    • 2
  • Stephen Malnick
    • 4
  • Leonid Kalichman
    • 5
  1. 1.Rheumatology UnitBarzilai Medical CenterAshkelonIsrael
  2. 2.Internal Medicine Department “D”Barzilai Medical CenterAshkelonIsrael
  3. 3.Gastroenterology UnitBarzilai Medical CenterAshkelonIsrael
  4. 4.Institute of Gastrointestinal and Liver Diseases and Medicine Department CKaplan HospitalRehovotIsrael
  5. 5.Department of Physical Therapy, Recanati School for Community Health Professions, Faculty of Health SciencesBen-Gurion University of the NegevBeer ShevaIsrael

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