Clinical Rheumatology

, Volume 28, Issue 5, pp 579–585 | Cite as

Risk factors of vertebral fractures in women with systemic lupus erythematosus

  • Claudia Mendoza-Pinto
  • Mario García-Carrasco
  • Hilda Sandoval-Cruz
  • Margarita Muñoz-Guarneros
  • Ricardo O. Escárcega
  • Mario Jiménez-Hernández
  • Pamela Munguía-Realpozo
  • Manuel Sandoval-Cruz
  • Margarita Delezé-Hinojosa
  • Aurelio López-Colombo
  • Ricard Cervera
Original Article


The aim of the current study was to analyze the role of traditional and systemic lupus erythematosus (SLE)-related risk factors in the development of vertebral fractures. A cross-sectional study was performed in women with SLE attending a single center. A vertebral fracture was defined as a reduction of at least 20% of vertebral body height. Two hundred ten patients were studied, with median age of 43 years and median disease duration of 72 months. Osteopenia was present in 50.3% of patients and osteoporosis in 17.4%. At least one vertebral fracture was detected in 26.1%. Patients with vertebral fractures had a higher mean age (50 ± 14 vs. 41 ± 13.2 years, p = 0.001), disease damage (57.1% vs. 34.4%, p = 0.001), lower bone mineral density (BMD) at the total hip (0.902 ± 0.160 vs. 982 ± 0.137 g/cm2, p = 0.002), and postmenopausal status (61.9% vs. 45.3%, p = 0.048). Stepwise logistic regression analysis revealed that only age (p = 0.001) and low BMD at the total hip (p = 0.007) remained as significant factors for the presence of vertebral fracture. The high prevalence of vertebral fractures in the relatively young population implies that more attention must be paid to detect and treat vertebral fractures.


Risk factors Systemic lupus erythematosus Vertebral fractures 





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Copyright information

© Clinical Rheumatology 2009

Authors and Affiliations

  • Claudia Mendoza-Pinto
    • 1
  • Mario García-Carrasco
    • 1
    • 2
  • Hilda Sandoval-Cruz
    • 3
  • Margarita Muñoz-Guarneros
    • 4
  • Ricardo O. Escárcega
    • 5
  • Mario Jiménez-Hernández
    • 1
    • 6
  • Pamela Munguía-Realpozo
    • 1
  • Manuel Sandoval-Cruz
    • 7
  • Margarita Delezé-Hinojosa
    • 8
  • Aurelio López-Colombo
    • 9
  • Ricard Cervera
    • 6
  1. 1.Systemic Autoimmune Diseases Research Unit, HGR #36, CMN Manuel Avila CamachoInstituto Mexicano del Seguro SocialPueblaMexico
  2. 2.Rheumatology and Immunology DepartmentBenemérita Universidad Autónoma de PueblaPueblaMexico
  3. 3.Radiology Unit, HGR #36, CMN Manuel Avila CamachoInstituto Mexicano del Seguro SocialPueblaMexico
  4. 4.State Research and PosgradoMedicine School Benemérita Universidad Autónoma de PueblaPueblaMexico
  5. 5.Internal MedicineTemple University HospitalPhiladelphiaUSA
  6. 6.Department of Autoimmune DiseasesInstitut Clínic de Medicina i Dermatologia, Hospital ClínicBarcelonaSpain
  7. 7.Internal Medicine Unit, HGR36, CMN Manuel Avila CamachoInstituto Mexicano del Seguro SocialPueblaMexico
  8. 8.Osteoporosis ClinicHospital AngelesPueblaMexico
  9. 9.State Research DepartamentInstituto Mexicano del Seguro SocialPueblaMexico

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