Clinical Rheumatology

, Volume 28, Issue 3, pp 353–356 | Cite as

The coexistence of ankylosing spondylitis and diffuse idiopathic skeletal hyperostosis—a postmortem diagnosis

  • Xavier Jordana
  • Ignasi Galtés
  • Ana Rita Couto
  • Luís Gales
  • Margarida Damas
  • Manuela Lima
  • Jácome Bruges-Armas
Case Report

Abstract

A 72-year-old male was diagnosed as having ankylosing spondylitis, mainly according to radiological findings, confirmed as HLA-B27-negative. Postmortem examination of the skeleton raised doubts on the initial diagnosis, since spinal findings pointed out also to diffuse idiopathic skeletal hyperostosis. The authors discuss the differential diagnosis and enhance the postmortem findings which allowed the diagnosis of the two clinical entities in the same patient.

Keywords

Bone pathology Joint fusion Sacroiliitis Spondyloarthropathy Syndesmophytes 

Notes

Acknowledgements

The authors wish to thank Dra. Monica Cos to help us in the interpretation of the radiological images, and Eng. Carlos M. Sá (CEMUP-UP) for the use of the SEM-XRM equipment and for his expertise. X Jordana is a Post-doctoral Fellow of the Fundação para a Ciência e Tecnologia (FCT), Portugal. Funding ref.: SFRH/BPD/26683/2006.

Conflict of interest

X Jordana, I Galtés, AR Couto, L Gales, M Damas, M Lima, J Bruges-Armas have no disclosures or conflicts of interest.

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Copyright information

© Clinical Rheumatology 2008

Authors and Affiliations

  • Xavier Jordana
    • 1
    • 2
  • Ignasi Galtés
    • 2
  • Ana Rita Couto
    • 3
    • 4
  • Luís Gales
    • 4
    • 5
  • Margarida Damas
    • 4
    • 5
  • Manuela Lima
    • 1
  • Jácome Bruges-Armas
    • 3
    • 4
  1. 1.Research Centre in Natural Resources (CIRN) and Department of BiologyUniversidade dos AçoresS. MiguelPortugal
  2. 2.Grup de Recerca en Osteobiografia (GROB), Unitat d’Antropologia BiològicaUniversitat Autònoma de BarcelonaBarcelonaSpain
  3. 3.Serviço Especializado de Epidemiologia e Biologia Molecular (SEEBMO)Hospital Santo EspíritoTerceiraPortugal
  4. 4.Institute for Molecular and Cell Biology (IBMC)Universidade do PortoPortoPortugal
  5. 5.Instituto de Ciências Biomédicas de Abel Salazar (ICBAS)Universidade do PortoPortoPortugal

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