Clinical Rheumatology

, 28:403 | Cite as

Cost-effectiveness modeling of abatacept versus other biologic agents in DMARDS and anti-TNF inadequate responders for the management of moderate to severe rheumatoid arthritis

  • Anthony Russell
  • Ariel Beresniak
  • Louis Bessette
  • Boulos Haraoui
  • Proton Rahman
  • Carter Thorne
  • Ross Maclean
  • Danielle Dupont
Original Article


To assess the cost-effectiveness of abatacept compared to different biologic treatment strategies for moderate to severe rheumatoid arthritis based on current medical practices in Canada. A model was constructed to assess the cost-effectiveness of various biologic treatments over a 2-year time horizon, using two effectiveness endpoints: “low disease activity state” (LDAS) and “remission”. Abatacept, as first biologic agent after an inadequate response to DMARDs, provides greater treatment success rate for achieving LDAS (29.4% versus 15.6%) and remission (14.8% versus 5.2%), and appears significantly more cost-effective compared to the sequential use of anti-TNF agents (p < 0.001). Abatacept, as second biologic agent after an inadequate response to one anti-TNF agent, provides greater treatment success rate for achieving LDAS (17.1% versus 10.2%) and remission (7.4% versus 3.9%) and appears significantly more cost-effective compared to the sequential use of anti-TNF agents (p < 0.001). Abatacept is a cost-effective strategy in patients with an inadequate response to DMARDs or to one anti-TNF agent.


Abatacept Anti-TNF therapy Cost-effectiveness Modeling Rheumatoid Arthritis 


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Copyright information

© Clinical Rheumatology 2008

Authors and Affiliations

  • Anthony Russell
    • 1
  • Ariel Beresniak
    • 2
    • 3
  • Louis Bessette
    • 4
  • Boulos Haraoui
    • 5
  • Proton Rahman
    • 6
  • Carter Thorne
    • 7
  • Ross Maclean
    • 8
  • Danielle Dupont
    • 9
  1. 1.University of AlbertaEdmontonCanada
  2. 2.LIRAESParis-Descartes UniversityParisFrance
  3. 3.Data Mining InternationalGenevaSwitzerland
  4. 4.Centre Hospitalier Universitaire de Québec-CHULQuébecCanada
  5. 5.University of MontrealMontrealCanada
  6. 6.St. Clare’s Mercy HospitalSt. John’sCanada
  7. 7.Southlake Regional Health CenterUniversity of TorontoTorontoCanada
  8. 8.Outcomes ResearchBristol-Myers SquibbPrincetonUSA
  9. 9.Bristol-Myers Squibb International CorporationBraine L’AlleudBelgium

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