Clinical Rheumatology

, Volume 27, Issue 1, pp 137–139 | Cite as

Phrenic nerve palsy in a patient of Churg Strauss syndrome and mononeuritis multiplex

  • Aman Sharma
  • Pradeep Bambery
  • Suryanarayana Bettadapura Shamanna
  • Ajay Wanchu
  • Surjit Singh
Case Report


Neurological manifestations like mononeuritis multiplex are seen commonly in patients with Churg Strauss syndrome. Cranial nerve involvement and central nervous system involvement are also reported, although infrequently. Phrenic nerve involvement has not been reported so far. We report a patient with Churg Strauss syndrome who presented with mononeuritis multiplex and developed left-sided phrenic nerve palsy subsequently.


Churg Strauss syndrome Mononeuritis multiplex Phrenic nerve palsy 


  1. 1.
    Masi AT, Hunder GG, Lie JT, Michel BA, Bloch DA, Arend WP, Calabrese LH, Edworthy SM, Fauci AS, Leavitt RY et al (1990) The American College of Rheumatology 1990 criteria for the classification of Churg–Strauss syndrome (allergic granulomatosis and angiitis). Arthritis Rheum 33:1094–100PubMedCrossRefGoogle Scholar
  2. 2.
    Churg J, Strauss L (1951) Allergic granulomatosis, allergic angiitis and periarteritis nodosa. Am J Pathol 27:277–301PubMedGoogle Scholar
  3. 3.
    Chumbley, LC, Harrison, EG, DeRemee, RA (1975) Allergic granulomatosis and angiitis (Churg Strauss Syndrome). Report of 30 cases. Mayo Clin Proc 52:477–484Google Scholar
  4. 4.
    Sehgal M, Swanson JW, DeRemee RA, Colby TV (1995) Neurological manifestations of Churg Strauss Syndrome. Mayo Clin Proc 70:337–341PubMedCrossRefGoogle Scholar
  5. 5.
    Lanham JG, Elkon KB, Pusey CD, Hughes GR (1984) Systemic vasculitis with asthma and eosinophilia. A clinical approach to Churg Strauss Syndrome. Medicine (Baltimore) 63:65–81Google Scholar
  6. 6.
    Guillevin L, Cohen P, Gayraud M, Lhote F, Jarrousse B, Casassus P (1999) Churg Strauss Syndrome. Clinical study and long term follow up of 96 patients. Medicine (Baltimore) 78:26–37CrossRefGoogle Scholar
  7. 7.
    Hattori N, Ichimura M, Nagamatsu M, Li M, Yamamoto K, Kumazawa K, Mitsuma T, Sobue G (1999) Clinicopathological features of Churg Strauss syndrome associated neuropathy. Brain 122:427–439PubMedCrossRefGoogle Scholar
  8. 8.
    Guillevin L, Pagnoux C (2003) When should immunosuppressants be prescribed to treat systemic vasculitides? Intern Med 42:313–317PubMedGoogle Scholar
  9. 9.
    Hoi AY, Morand EF (2003) Churg-Strauss syndrome: the use of cyclophosphamide in mononeuritis. Rheumatology (Oxford) 42:390–391CrossRefGoogle Scholar
  10. 10.
    Loo KL, Ramachandran R, Chow SK, Goh EM, Yeap SS (2004) Mononeuritis in Churg–Strauss syndrome in Asians responding to intravenous cyclophosphamide. Rheumatology (Oxford) 43:251–252CrossRefGoogle Scholar

Copyright information

© Clinical Rheumatology 2007

Authors and Affiliations

  • Aman Sharma
    • 1
  • Pradeep Bambery
    • 1
  • Suryanarayana Bettadapura Shamanna
    • 1
  • Ajay Wanchu
    • 1
  • Surjit Singh
    • 1
  1. 1.Department of Internal MedicinePost Graduate Institute of Medical Education and ResearchChandigarhIndia

Personalised recommendations