Clinical Rheumatology

, Volume 26, Issue 11, pp 1921–1924 | Cite as

Association of interferon-gamma gene polymorphism (+874A) with arthritis manifestation in SLE

  • Marut Tangwattanachuleeporn
  • Pimpayao Sodsai
  • Yingyos Avihingsanon
  • Jongkonnee Wongpiyabovorn
  • Jeerapat Wongchinsri
  • Nattiya Hirankarn
Brief Report


Systemic lupus erythematosus (SLE) is a complex autoimmune disease in which genetic factors strongly influence susceptibility. Cytokines such as the interferon-gamma (IFNG) gene play a key role in controlling the immunity and inflammation, and therefore their polymorphisms may affect these genes’ expression levels among individuals. We investigated the frequency of IFNG gene intron (+874) polymorphism, previously reported to be associated with IFNG production, in SLE patients compared to a control group. This population-based case–control study includes 154 SLE patients and 154 healthy control subjects with similar ethnic backgrounds. The genotyping was determined by polymerase chain reaction sequence-specific primer method and using the Chi-squared test for analyzing the association between this single-nucleotide polymorphism and SLE. The allele frequencies of the IFNG (+874) gene polymorphism were not significantly different between SLE patients and control subjects (72.7 vs 77%). However, there was a significant association between A dominance model of inheritance with arthritis (odds ratio = 7.64, 95% confidence interval = 1.56–41.64, P = 0.006, P c = 0.03). The result suggested that the +874 intron polymorphism of IFNG can be used as the marker for SLE susceptibility with arthritis in the Thai population.


Interferon-gamma Polymorphisms SLE Thai population 



This study was supported by the Human Genetics grant from National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand, Ministry of University Affairs (MUA)–CU Thesis Grant 2002, and Lupus Research Unit, Chulalongkorn University. The authors wish to thank all the patients for their cooperation.


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Copyright information

© Clinical Rheumatology 2007

Authors and Affiliations

  • Marut Tangwattanachuleeporn
    • 1
    • 2
  • Pimpayao Sodsai
    • 1
    • 2
  • Yingyos Avihingsanon
    • 1
    • 3
  • Jongkonnee Wongpiyabovorn
    • 1
    • 4
  • Jeerapat Wongchinsri
    • 5
  • Nattiya Hirankarn
    • 1
    • 4
  1. 1.Lupus Research Unit, Department of Microbiology, Faculty of MedicineChulalongkorn UniversityBangkokThailand
  2. 2.Inter-department of Medical Microbiology, Graduate SchoolChulalongkorn UniversityBangkokThailand
  3. 3.Department of Medicine, Faculty of MedicineChulalongkorn UniversityBangkokThailand
  4. 4.Department of Microbiology, Faculty of MedicineChulalongkorn UniversityBangkokThailand
  5. 5.Department of MedicineNopparat Rajathanee HospitalBangkokThailand

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