Anxiety and depression in patients with rheumatoid arthritis
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Rheumatoid arthritis (RA) mostly follows a painful, progressively disabling course, and individuals with RA experience more psychological distress than healthy individuals. The objective of the present study is to examine the prevalences of accompanying anxiety and depression in RA cases. The study included 82 RA cases and 41 age- and sex-matched healthy volunteers as the control group. Psychiatric examinations of all cases of the patient and control groups were performed according to DSM-IV criteria. Hamilton Anxiety Scale or Hamilton Depression Scale was applied to those who were found to have anxiety or depression. Total prevalence of anxiety, depression, and mixed anxiety-depressive disorder was found to be 70.8% (n=58) in the patient group and 7.3% (n=3) in the control group, and the difference was significant (p<0.001). Of the RA patients, 41.5% (n=34) was found to have depression, 13.4% (n=11) anxiety, and 15.9% (n=13) mixed anxiety-depressive disorder. The disease duration in patients with anxiety was shorter than the RA patient with depression (p<0.05). The disease duration was positively correlated with the degree of depression and negatively correlated with the degree of anxiety (r=0.341, p<0.05; r=−0.642, p<0.05, respectively). The results of our study suggest that prevalences of anxiety and mainly depression, increase in RA cases. When the clinical picture in RA cases becomes complicated with anxiety or depression, some problems at patients’ adaptation and response to treatment may be possible. RA cases should be monitored for accompanying anxiety or depression during follow-up.
KeywordsAnxiety Depression Rheumatoid arthritis
We thank Murad Atmaca M.D. of the Department of Psychiatry for his contributions.
- 15.Alloy LB, Kelly KA, Mineka S, Clements CM (1990) Comorbidity of anxiety and depressive disorders: a helplessness–hopelessness perspective. In: Maser JD, Cloniger CR (eds) Comorbidity of mood and anxiety disorders. American Psychiatric, Washington, DC, pp 499–543Google Scholar
- 20.America Psychiatric Association. DSM-IV: Diagnostic and Statistical manual of mental disorders, 4th edn. Washington, DC, 1994Google Scholar
- 34.Dunn AJ, Wang J, Ando T (1999) Effects of cytokines on cerebral neurotransmission. Comparison with the effects of stress. In: Dantzer R, Wollman EE, Yirmiya R (eds) Cytokines, stress and depression. Academic/Plenum, New York, pp 117–127Google Scholar
- 35.Bonaccorso S, Puzella A, Marino V, Pasquini M, Biondi M, Artini M et al (2001) Immunotherapy with interferon-alpha in patients affected by chronic hepatitis C induces an intercorrelated stimulation of the cytokine network and an increase in depressive and anxiety symptoms. Psychiatry Res 105(1–2):45–55PubMedCrossRefGoogle Scholar
- 48.Klein JF (1992) Adverse psychiatric effects of systemic glucocorticoid therapy. Am Fam Phys 46(5):1469–1474Google Scholar