Nephropathy, polyneuropathy, and gastroenteritis in a child with Churg–Strauss syndrome
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Churg–Strauss syndrome (CSS) is a serious but rare pauci-immune vasculitis of small- and medium-sized blood vessels. It is commonly seen in association with bronchial asthma and/or allergic disorders. The syndrome is characterized by the presence of asthma, hypereosinophilia, and vasculitis in any part of the body. Vasculitis is often associated with significant distortion of normal functions. A rather severe case of CSS in an 8-year-old Nigerian girl with asthma and allergic rhinoconjunctivitis is reported. She presented with multiple morbidities, namely, vasculitic polyneuropathy and also nephritic–nephrotic syndrome that eventuated in acute renal failure after an onset of vasculitic gastroenteritis. Routine screening of all asthmatic patients for CSS is advocated.
KeywordsAsthma Diarrhea Glomerulonephritis Hypereosinophilia Quadriparesis Rhinoconjunctivitis
- 3.Lanham JG, Elkon KB, Pusey CD (1984) Systemic vasculitis with asthma and eosinophilia: a clinical approach to the Churg–Strauss Syndrome. Medicine (Baltimore) 420:65–81Google Scholar
- 5.Jennette JC (1998) Renal involvement in systemic vasculitis. In: Heptinstall’s pathology of the kidney. Lippincott-Raven, Philadelphia, pp 1059–1095Google Scholar
- 6.National Institute of Health (1997) National Asthma Education and Prevention Programme, Expert Panel Report 2: Guidelines for the Diagnosis and Management of Asthma. NIH Publication No. 97-4053, Bethesda, MD, pp 1–52Google Scholar
- 8.Drazen J (1998) Clinical pharmacology of leukotriene receptor antagonists and 5-lipoxygenase inhibitors. Am J Respir Crit Care Med 157:S233–S237Google Scholar