Clinical Rheumatology

, Volume 26, Issue 5, pp 831–835 | Cite as

Nephropathy, polyneuropathy, and gastroenteritis in a child with Churg–Strauss syndrome

Case report

Abstract

Churg–Strauss syndrome (CSS) is a serious but rare pauci-immune vasculitis of small- and medium-sized blood vessels. It is commonly seen in association with bronchial asthma and/or allergic disorders. The syndrome is characterized by the presence of asthma, hypereosinophilia, and vasculitis in any part of the body. Vasculitis is often associated with significant distortion of normal functions. A rather severe case of CSS in an 8-year-old Nigerian girl with asthma and allergic rhinoconjunctivitis is reported. She presented with multiple morbidities, namely, vasculitic polyneuropathy and also nephritic–nephrotic syndrome that eventuated in acute renal failure after an onset of vasculitic gastroenteritis. Routine screening of all asthmatic patients for CSS is advocated.

Keywords

Asthma Diarrhea Glomerulonephritis Hypereosinophilia Quadriparesis Rhinoconjunctivitis 

References

  1. 1.
    Watts RA, Scott DGI (2003) Epidemiology of the vasculitides. Curr Opin Rheumatol 15:11–16PubMedCrossRefGoogle Scholar
  2. 2.
    Churg J, Strauss L (1951) Allergic granulomatosis, allergic angiitis, and periarteritis nodosa. Am J Pathol 27:277–294PubMedGoogle Scholar
  3. 3.
    Lanham JG, Elkon KB, Pusey CD (1984) Systemic vasculitis with asthma and eosinophilia: a clinical approach to the Churg–Strauss Syndrome. Medicine (Baltimore) 420:65–81Google Scholar
  4. 4.
    Masi AT, Hunder GG, Lie JT et al (1990) The American College of Rheumatology 1990 criteria for the classification of Churg–Strauss Syndrome (allergic granulomatosis and angiitis). Arthritis Rheum 33:1094–1100PubMedCrossRefGoogle Scholar
  5. 5.
    Jennette JC (1998) Renal involvement in systemic vasculitis. In: Heptinstall’s pathology of the kidney. Lippincott-Raven, Philadelphia, pp 1059–1095Google Scholar
  6. 6.
    National Institute of Health (1997) National Asthma Education and Prevention Programme, Expert Panel Report 2: Guidelines for the Diagnosis and Management of Asthma. NIH Publication No. 97-4053, Bethesda, MD, pp 1–52Google Scholar
  7. 7.
    Seminario MC, Gleich GJ (1994) The role of eosinophils in the pathogenesis of asthma. Curr Opin Immunol 6:860–864PubMedCrossRefGoogle Scholar
  8. 8.
    Drazen J (1998) Clinical pharmacology of leukotriene receptor antagonists and 5-lipoxygenase inhibitors. Am J Respir Crit Care Med 157:S233–S237Google Scholar
  9. 9.
    Smith LJ (1998) A risk–benefit assessment of anti-leukotrienes in asthma. Drug Saf 19:205–218PubMedCrossRefGoogle Scholar
  10. 10.
    Jamaleddine G, Diab K, Tabbarah Z et al (2002) Leukotriene antagonists and the Churg–Strauss syndrome. Semin Arthritis Rheum 31:218–227PubMedCrossRefGoogle Scholar
  11. 11.
    Churg A, Brallas M, Cronin SR et al (1995) Formes frustes of Churg–Strauss syndrome. Chest 108:320–323PubMedGoogle Scholar
  12. 12.
    Loughlin JE, Cole JA, Rothman KJ et al (2002) Prevalence of serious eosinophilia and incidence of Churg–Strauss syndrome in a cohort of asthma patients. Ann Allergy Asthma Immunol 83:319–325CrossRefGoogle Scholar

Copyright information

© Clinical Rheumatology 2006

Authors and Affiliations

  1. 1.Paediatric Nephrology and Hypertension UnitObafemi Awolowo University Teaching Hospitals ComplexIle-IfeNigeria

Personalised recommendations