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Clinical Rheumatology

, Volume 26, Issue 2, pp 225–230 | Cite as

Pulmonary involvement in ankylosing spondylitis

  • Percival D. Sampaio-BarrosEmail author
  • Elza Maria F. P. Cerqueira
  • Sílvio M. Rezende
  • Lucimara Maeda
  • Roseneide A. Conde
  • Verônica A. Zanardi
  • Manoel Barros Bértolo
  • José Ribeiro de Menezes Neto
  • Adil M. Samara
Original article

Abstract

This is a prospective study analyzing 52 asymptomatic, consecutive patients with ankylosing spondylitis (AS), who submitted to a pulmonary investigation that included plain chest radiography, pulmonary function test (PFT), and thoracic high-resolution computed tomography (HRCT). The results were compared according to sex, race, dorsal spine involvement, thoracic diameter, smoking status, and HLA-B27. There were four patients (8%) with an altered plain chest radiograph. PFT presented a restrictive pattern in 52% of the patients. Thoracic HRCT showed abnormalities in 21 patients (40%), predominantly nonspecific linear parenchymal opacities (19%), lymphadenopathy (12%), emphysema (10%), bronchiectasis (8%), and pleural involvement (8%). Linear parenchymal opacities were associated with a smoking history (p=0.026) and dorsal spine involvement (p=0.032). HLA-B27 was not associated with any abnormality. A lower thoracic diameter was observed in patients with dorsal spine involvement (p=0.0001), restrictive pattern at PFT (p=0.023), and linear parenchymal opacities (p=0.015). The study concluded that nonspecific subclinical pulmonary involvement is frequent in AS.

Keywords

Ankylosing spondylitis High-resolution computed tomography Lung involvement Pulmonary function test 

Notes

Acknowledgements

The authors would like to thank Helymar C. Machado and Andreia Semolini for the statistical analysis of this study.

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Copyright information

© Clinical Rheumatology 2006

Authors and Affiliations

  • Percival D. Sampaio-Barros
    • 1
    Email author
  • Elza Maria F. P. Cerqueira
    • 2
  • Sílvio M. Rezende
    • 3
  • Lucimara Maeda
    • 2
  • Roseneide A. Conde
    • 1
  • Verônica A. Zanardi
    • 2
  • Manoel Barros Bértolo
    • 1
  • José Ribeiro de Menezes Neto
    • 2
  • Adil M. Samara
    • 1
  1. 1.Unit of Rheumatology, Department of Internal MedicineState University of Campinas Faculty of Medical Sciences (FCM / UNICAMP)Barão GeraldoBrazil
  2. 2.Department of RadiologyState University of Campinas Faculty of Medical Sciences (FCM / UNICAMP)Barão GeraldoBrazil
  3. 3.Unit of Pneumology, Department of Internal MedicineState University of Campinas Faculty of Medical Sciences (FCM / UNICAMP)Barão GeraldoBrazil

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