Clinical Rheumatology

, Volume 26, Issue 6, pp 1027–1028 | Cite as

Ascending aortic aneurysm in a man with scleroderma

  • Robert R. AttaranEmail author
  • David Guarraia
Case report


Macrovascular involvement in scleroderma has received relatively little attention. We hereby describe a 5.6-cm ascending aortic aneurysm in a 56-year-old man presenting with increased dyspnea, diagnosed with antibody-negative, rapidly progressive diffuse cutaneous scleroderma. The patient had sclerosis and induration of all extremities, face, thorax and abdomen. Other features included Raynaud’s phenomenon, arthralgia, dysphagia, dyspnea attributed to pulmonary fibrosis, pericardial effusion, and cardiomyopathy. To the best of our knowledge, there is only one other report to date in the English language of a thoracic aortic aneurysm associated with scleroderma.


Aneurysm Aorta Scleroderma Systemic sclerosis 


  1. 1.
    Subcommittee for Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee (1980) Preliminary criteria for the classification of systemic sclerosis (scleroderma). Arthritis Rheum 23(5):581–590CrossRefGoogle Scholar
  2. 2.
    Nadashkevich O, Davis P, Fritzler M (2004) A proposal of criteria for the classification of systemic sclerosis. Med Sci Monit 10(11):CR615–CR621PubMedGoogle Scholar
  3. 3.
    Abraham DJ, Varga J (2005) Scleroderma: from cell and molecular mechanisms to disease models. Trends Immunol 26(11):587–595CrossRefPubMedGoogle Scholar
  4. 4.
    Bickerstaff LK, Pairolero PC, Hollier et al (1982) Thoracic aortic aneurysms: a population-based study. Surgery 92:1103–1108PubMedGoogle Scholar
  5. 5.
    Crawford ES, DeNatale RW (1986) Thoracoabdominal aortic aneurysm: observations regarding the natural course of the disease. J Vasc Surg 3(4):578–582CrossRefPubMedGoogle Scholar
  6. 6.
    Klima T, Spjut HJ, Coelho A et al (1983) The morphology of ascending aortic aneurysms. Hum Pathol 14(9):810–817PubMedCrossRefGoogle Scholar
  7. 7.
    Davies MJ (1998) Aortic aneurysm formation: lessons from human studies and experimental models. Circulation 98(3):193–195PubMedGoogle Scholar
  8. 8.
    Isselbacher EM (2005) Thoracic and abdominal aortic aneurysms. Circulation 111:816–828CrossRefPubMedGoogle Scholar
  9. 9.
    Kaku Y, Kouda K, Yoshimura S et al (2004) Cerebral aneurysms in scleroderma. Cerebrovasc Dis 17:339–341CrossRefPubMedGoogle Scholar
  10. 10.
    Chaithiraphan S, Goldberg E, O’Reilly M et al (1973) Multiple aneurysms of coronary artery in sclerodermal heart disease. Angiology 2:86–93Google Scholar
  11. 11.
    Seo Y, Lee, S, Yoo W (2005) Thoracoabdominal aortic aneurysm associated with systemic sclerosis. Rheumatology 44(11):1459–1461CrossRefPubMedGoogle Scholar
  12. 12.
    Cheng KS, Tiwari A, Boutin A, Denton CP et al (2003) Carotid and femoral arterial wall mechanics in scleroderma. Rheumatology 42:1299–1305CrossRefPubMedGoogle Scholar
  13. 13.
    Ho M, Veale D, Eastmond C et al (2000) Macrovascular disease and systemic sclerosis. Ann Rheum Dis 59:39–43CrossRefPubMedGoogle Scholar
  14. 14.
    Youssef P, Brama T, Englert H et al (1995) Limited scleroderma is associated with increased prevalence of macrovascular disease. J Rheumatol 22:469–472PubMedGoogle Scholar

Copyright information

© Clinical Rheumatology 2006

Authors and Affiliations

  1. 1.The University of Arizona Affiliated HospitalsTucsonUSA
  2. 2.Graduate Medical Education DepartmentUniversity Medical CenterTucsonUSA

Personalised recommendations