Clinical Rheumatology

, Volume 26, Issue 1, pp 50–54 | Cite as

Kikuchi–Fujimoto Disease: analysis of 244 cases

  • Yasar Kucukardali
  • Emrullah Solmazgul
  • Erdogan KunterEmail author
  • Oral Oncul
  • Sukru Yildirim
  • Mustafa Kaplan
Original Article


Kikuchi–Fujimoto Disease (KFD) was first described in Japan in 1972. The disease frequently mimics tuberculous lymphadenitis, malign lymphoma, and many other benign and malignant conditions. To our knowledge, there is no previous study comparing the clinical and laboratory characteristics of patients from different geographical parts of the world. We searched literature records beginning from 1991 and analyzed epidemiological, clinical, and laboratory data of 244 patients (including cases diagnosed in our institution) reported in 181 publications. Of the 244 cases, 33% were male and 77% were female. Mean age was 25 (1–64) and 70% was younger than 30. Most of the cases were reported from Taiwan (36%), USA (6.6%), and Spain (6.3%). Fever (35%), fatigue (7%) and joint pain (7%) were the most frequent symptoms, while lymphadenomegaly (100%), erythematous rashes (10%), arthritis (5%), hepatosplenomegaly (3%), leucopenia (43%), high erythrocyte sedimentation rate (40%), and anemia (23%) being the most common findings. KFD was associated with SLE (32 cases), non-infectious inflammatory diseases (24 cases), and viral infections (17 cases). SLE was more frequent in cases from Asia than Europe (28 and 9%, respectively). The disease was self-limiting in 156 (64%) and corticosteroid treatment was necessary in 16 (16%) of the cases. The mortality rate was 2.1%. Early diagnosis is crucial as the clinical and laboratory presentation generally imitates situations needing lengthy and costly diagnostic and therapeutic interventions. Additionally, association with SLE needs further investigation.


Fujimoto Histiocytic lymphadenitis Kikuchi 


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Copyright information

© Clinical Rheumatology 2006

Authors and Affiliations

  • Yasar Kucukardali
    • 1
  • Emrullah Solmazgul
    • 1
  • Erdogan Kunter
    • 2
    • 5
    Email author
  • Oral Oncul
    • 3
  • Sukru Yildirim
    • 4
  • Mustafa Kaplan
    • 1
  1. 1.Internal MedicineGata Haydarpasa Training HospitalIstanbulTurkey
  2. 2.Respiratory DiseasesGata Haydarpasa Training HospitalIstanbulTurkey
  3. 3.Infectious DiseasesGata Haydarpasa Training HospitalIstanbulTurkey
  4. 4.PathologyGata Haydarpasa Training HospitalIstanbulTurkey
  5. 5.Acibadem caddesiIstanbulTurkey

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