Clinical Rheumatology

, Volume 25, Issue 1, pp 70–74 | Cite as

Calcinosis cutis universalis in a patient with systemic lupus erythematosus

  • Antonio G. Tristano
  • José L. Villarroel
  • María A. Rodríguez
  • Alberto Millan
Case Report

Abstract

Deposition of calcium salts in the skin and subcutaneous tissue occurs in a variety of rheumatic diseases, being most commonly associated with scleroderma, CREST (calcinosis, Raynaud’s phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia), dermatomyositis, and overlap syndromes but is a rare complication of systemic lupus erythematosus (SLE). Calcinosis is classified into four subsets: dystrophic, metastatic, idiopathic, or calciphylaxis/iatrogenic. The pathophysiology of calcinosis cutis remains unclear. Our patient developed extensive areas of calcifications in the trunk and extremities (calcinosis universalis) 8 years after SLE diagnosis, which would correspond to a form of dystrophic calcification. No response was observed after treatment with oral diltiazem for 3 months. We review the literature on the pathogenesis and prevalence of calcinosis universalis in SLE.

Keywords

Calcinosis cutis Calcinosis universalis Leg ulcers Systemic lupus erythematosus 

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Copyright information

© Clinical Rheumatology 2005

Authors and Affiliations

  • Antonio G. Tristano
    • 1
    • 5
  • José L. Villarroel
    • 2
  • María A. Rodríguez
    • 3
  • Alberto Millan
    • 2
    • 4
  1. 1.Servicio de Medicina InternaHospital Dr. Domingo LucianiCaracasVenezuela
  2. 2.Servicio de ReumatologíaHospital Universitario de CaracasCaracasVenezuela
  3. 3.Servicio de DermatologíaHospital Universitario de CaracasCaracasVenezuela
  4. 4.Servicio de Medicina InternaHospital Universitario de CaracasCaracasVenezuela
  5. 5.MiamiUSA

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