Clinical Rheumatology

, Volume 24, Issue 6, pp 641–644 | Cite as

Immune thrombocytopenic purpura associated with rheumatoid arthritis: case report

  • Taro Horino
  • Atsushi Sasaoka
  • Toshihiro Takao
  • Takafumi Taguchi
  • Hiroshi Maruyama
  • Hiroyuki Ito
  • Shigeki Takemoto
  • Hirokuni Taguchi
  • Kozo Hashimoto
Case Report

Abstract

A 54-year-old Japanese woman was diagnosed with rheumatoid arthritis (RA) in 1995 on the basis of symmetric effusive polyarthritis, morning stiffness, and strongly positive rheumatoid factor. She had received low-dose prednisolone, indomethacin, methotrexate (MTX), and cyclophosphamide (CPA), at least, over 4 years before the current admission and showed partial improvement of polyarthralgia. In November 2002, she suddenly developed thrombocytopenia (platelet count was 0.3×104 mm−3) with purpura and was diagnosed with immune thrombocytopenic purpura (ITP). As she had refractory ITP, the administration of pulsed high-dose dexamethasone (DEX) therapy was started, resulting in the complete remission of ITP. The present paper reports that pulsed high-dose DEX therapy was useful for the treatment of refractory ITP associated with RA.

Keywords

Immune thrombocytopenic purpura Pulsed high-dose dexamethasone therapy Rheumatoid arthritis 

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Copyright information

© Clinical Rheumatology 2005

Authors and Affiliations

  • Taro Horino
    • 1
  • Atsushi Sasaoka
    • 1
  • Toshihiro Takao
    • 1
  • Takafumi Taguchi
    • 1
  • Hiroshi Maruyama
    • 1
  • Hiroyuki Ito
    • 1
  • Shigeki Takemoto
    • 2
  • Hirokuni Taguchi
    • 2
  • Kozo Hashimoto
    • 1
  1. 1.Department of Endocrinology, Metabolism and NephrologyKochi Medical SchoolKochiJapan
  2. 2.Department of Hematology and Respiratory MedicineKochi Medical SchoolKochiJapan

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