Clinical Rheumatology

, Volume 26, Issue 4, pp 601–603 | Cite as

Additive contribution of multiple factors in the development of pneumatosis intestinalis: a case report and review of the literature

  • Masataka Saito
  • Akiko Tanikawa
  • Katsuki Nakasute
  • Masaru Tanaka
  • Takeji Nishikawa
Case Report

Abstract

We describe a 53-year-old patient with dermatomyositis, who developed pneumatosis intestinalis (PI) accompanied by pneumoperitoneum, pneumoretroperitoneum, pneumomediastinum, and subcutaneous emphysema of the neck. The development of PI in our patient was possibly attributed to the effect of factors such as dermatomyositis, corticosteroids, methotrexate, and alpha-glucosidase inhibitor (AGI). The coexistence of multiple factors associated with PI might enhance the risk of developing PI, even though each of them alone is not sufficient to induce it. In particular, the use of AGIs for patients treated with immunosuppressive agents such as corticosteroids requires evaluation.

Keywords

Alpha-glucosidase inhibitor Corticosteroids Dermatomyositis Diabetes mellitus Methotrexate Pneumatosis intestinalis 

References

  1. 1.
    Sequira W (1990) Pneumatosis cystoides intestinalis in systemic sclerosis and other disorders. Semin Arthritis Rheum 19:269–276CrossRefPubMedGoogle Scholar
  2. 2.
    St Peter SD, Abbas MA, Kelly KA (2003) The spectrum of pneumatosis intestinalis. Arch Surg 138:68–75PubMedCrossRefGoogle Scholar
  3. 3.
    Heng Y, Schuffler MD, Haggitt RC, Rohrmann CA (1995) Pneumatosis intestinalis: a review. Am J Gastroenterol 90:1747–1758PubMedGoogle Scholar
  4. 4.
    Cabrera GE, Scopelitis E, Cuellar ML, Silveira LH, Mena H, Espinoza LR (1994) Pneumatosis cystoides intestinalis in systemic lupus erythematosus with intestinal vasculitis: treatment with high dose prednisone. Clin Rheumatol 13:312–316PubMedGoogle Scholar
  5. 5.
    Pasquier E, Wattiaux MJ, Peigney N (1993) First case of pneumatosis cystoides intestinalis in adult dermatomyositis. J Rheumatol 20:499–503PubMedGoogle Scholar
  6. 6.
    Morris-Stiff GJ, Williams RJ (1999) Pneumatosis cystoides intestinalis in a patient with dermatomyositis. J R Soc Med 92:366–367PubMedGoogle Scholar
  7. 7.
    Vincent F, Duboust A, Glotz D (1995) Pneumatosis cystoides intestinalis and immunosuppression. Am J Gastroenterol 90:522–523PubMedGoogle Scholar
  8. 8.
    Ammons MA, Bauling PC, Weil R 3rd (1986) Pneumatosis cystoides intestinalis with pneumoperitoneum in renal transplant patients on cyclosporine and prednisone. Transplant Proc 18:1868–1870PubMedGoogle Scholar
  9. 9.
    Yanaru R, Hizawa K, Nakamura S, Yoshimura R, Watanabe K, Nakamura U et al (2002) Regression of pneumatosis cystoides intestinalis after discontinuing of alpha-glucosidase inhibitor administration. J Clin Gastroenterol 35:204–205CrossRefPubMedGoogle Scholar
  10. 10.
    Joubert PH, Venter HL, Foukaridis GN (1990) The effect of miglitol and acarbose after an oral glucose load: a novel hypoglycaemic mechanism? Br J Clin Pharmacol 30:391–396PubMedGoogle Scholar
  11. 11.
    Forgacs P, Wright PH, Wyatt AP (1973) Treatment of intestinal gas cysts by oxygen breathing. Lancet 1:579–582PubMedGoogle Scholar

Copyright information

© Clinical Rheumatology 2005

Authors and Affiliations

  • Masataka Saito
    • 1
  • Akiko Tanikawa
    • 1
  • Katsuki Nakasute
    • 1
  • Masaru Tanaka
    • 1
  • Takeji Nishikawa
    • 1
  1. 1.Department of DermatologyKeio University School of MedicineTokyoJapan

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