Clinical Rheumatology

, Volume 25, Issue 5, pp 683–686

Comparison of the analgesic efficacy of pamidronate and synthetic human calcitonin in osteoporotic vertebral fractures: a double-blind controlled study

  • M. Laroche
  • S. Cantogrel
  • B. Jamard
  • A. Constantin
  • L. Zabraniecki
  • A. Cantagrel
  • B. Mazières
Original Article

DOI: 10.1007/s10067-005-0159-0

Cite this article as:
Laroche, M., Cantogrel, S., Jamard, B. et al. Clin Rheumatol (2006) 25: 683. doi:10.1007/s10067-005-0159-0

Abstract

Our aim was to compare the analgesic efficacy of pamidronate (PAM) and synthetic human calcitonin (CT) in intravenous infusion for recent painful benign vertebral compression in a randomised prospective double-blind study. Twenty-seven patients aged 49–85 years with painful benign non-traumatic vertebral compression were included in the study. They received either PAM (1 mg/kg) or synthetic human CT (1.5 mg) as an intravenous infusion. Pain and functional disability were evaluated before infusion, and 4 and 30 days afterwards. The pain score assessed on a visual analogue scale at day 0 was 5.94±2.47 in patients treated with PAM and 6.27±2.50 in patients treated with CT (p=0.74); at day 4, 4.8±2.80 with PAM vs 3.9±2.68 with CT (p=0.37); and at day 30, 3.6±3.13 with PAM vs 3.10±2.76 with CT (p=0.70). Spinal function scores were 18.21±3.17 at day 0 in patients treated with PAM vs 17.23±4.42 in patients treated with CT (p=0.69) and at day 30, 13.7±5.36 with PAM vs 12.33±3.22 with CT (p=0.68). We found no advantage of PAM over CT in a single intravenous infusion for the treatment of painful recent benign vertebral compression. Since CT is ten times less costly, its use should be preferred.

Keywords

vertebral fractures pain pamidronate calcitonin 

Copyright information

© Clinical Rheumatology 2006

Authors and Affiliations

  • M. Laroche
    • 1
  • S. Cantogrel
    • 1
  • B. Jamard
    • 1
  • A. Constantin
    • 1
  • L. Zabraniecki
    • 2
  • A. Cantagrel
    • 1
  • B. Mazières
    • 1
  1. 1.Service de RhumatologieCHU RangueilToulouseFrance
  2. 2.Service de RhumatologieCHU PurpanToulouseFrance

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