Clinical Rheumatology

, Volume 26, Issue 3, pp 443–444 | Cite as

Psoriatic arthritis and Klinefelter syndrome: case report

  • N. Melillo
  • A. Corrado
  • L. Quarta
  • F. D’Onofrio
  • F. P. CantatoreEmail author
Case Report


Psoriatic arthritis (PsA) is a well-known disease characterized by psoriasis and inflammatory joint disease, with distinct clinical and radiological features to differentiate it from other arthropathies. Whereas many cases of coexistence of arthritis and other autoimmune disorders with chromosomal abnormalities have been reported, the occurrence of PsA and Klinefelter syndrome has not been reported previously. A case of Klinefelter syndrome and PsA was reported. This case report emphasizes the role played by sex hormones and chromosomal abnormalities in the pathogenesis of autoimmune disorder, and to our knowledge, this is an uncommon case of a patient with Klinefelter syndrome who developed PsA.


Chromosomal abnormalities Klinefelter syndrome Psoriatic arthritis Sexual hormones 



Psoriatic arthritis


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Copyright information

© Clinical Rheumatology 2006

Authors and Affiliations

  • N. Melillo
    • 1
  • A. Corrado
    • 1
  • L. Quarta
    • 1
  • F. D’Onofrio
    • 1
  • F. P. Cantatore
    • 1
    Email author
  1. 1.Department of RheumatologyUniversity of Foggia “D’Avanzo” HospitalFoggiaItaly

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