Advertisement

Clinical Rheumatology

, Volume 26, Issue 3, pp 443–444 | Cite as

Psoriatic arthritis and Klinefelter syndrome: case report

  • N. Melillo
  • A. Corrado
  • L. Quarta
  • F. D’Onofrio
  • F. P. Cantatore
Case Report

Abstract

Psoriatic arthritis (PsA) is a well-known disease characterized by psoriasis and inflammatory joint disease, with distinct clinical and radiological features to differentiate it from other arthropathies. Whereas many cases of coexistence of arthritis and other autoimmune disorders with chromosomal abnormalities have been reported, the occurrence of PsA and Klinefelter syndrome has not been reported previously. A case of Klinefelter syndrome and PsA was reported. This case report emphasizes the role played by sex hormones and chromosomal abnormalities in the pathogenesis of autoimmune disorder, and to our knowledge, this is an uncommon case of a patient with Klinefelter syndrome who developed PsA.

Keywords

Chromosomal abnormalities Klinefelter syndrome Psoriatic arthritis Sexual hormones 

Abbreviation

PsA

Psoriatic arthritis

References

  1. 1.
    Helliwell P, Marchesoni A, Peters M, Barker M, Wright V (1991) A re-evaluation of the osteoarticular manifestation of psoriasis. Br J Rheumatol 30:339–345PubMedCrossRefGoogle Scholar
  2. 2.
    Bosmansky K, Kopecky S (1979) Progressive polyarthritis and Klinefelter’s syndrome. Fysiatr Revmatol Vestn 57(3):160–163PubMedGoogle Scholar
  3. 3.
    Linchiardopol C, Mota M, Panus C (2004) Metabolic changes in Klinefelter syndrome. Rom J Internal Med 42(2):415–422Google Scholar
  4. 4.
    Adarichev VA, Nesterovitch AB, Bardos T, Biesczat D, Chandrasekaran R, Vermes C, Mikecz K, Finnegan A, Grant TT (2003) Sex effect on clinical and immunologic quantitative trait loci in a murine model of rheumatoid arthritis. Arthritis Rheum 48(6):1708–1720CrossRefPubMedGoogle Scholar
  5. 5.
    Holmdhal R, Jansson L, Andersso M, Jonsson R (1992) Genetic, hormonal and behavioural influence on spontaneously developing arthritis in normal mice. Clin Exp Immunol 88(3):472–476Google Scholar
  6. 6.
    Masi AT, Chatterton RT, Aldag JC (1999) Perturbation of hypothalamic–pituitary–gonadal axis and adrenal androgen function in rheumatoid arthritis: an odyssey of hormonal relationship to the disease. Ann N Y Acad Sci 876:52–53CrossRefGoogle Scholar
  7. 7.
    Dessein PH, Joffe BI, Stanwix AE, Moomal Z (2001) Hyposecretion of adrenal androgen dehydroepiandrosterone sulfate and its relation to clinical variables in inflammatory arthritis. Arthritis Res 3(3):183–188CrossRefPubMedGoogle Scholar
  8. 8.
    Cutolo M, Seiolo B, Pizzorni C, Sulli A (2001) The role of androgen in rheumatic disease. Isr Med Assoc J 3:743–748PubMedGoogle Scholar
  9. 9.
    Kanda N, Tsuchida T, Tamaki K (1996) Testosterone inhibits immunoglobulin production by human peripheral blood mononuclear cells. Clin Exp Immunol 106(2):410CrossRefPubMedGoogle Scholar
  10. 10.
    Cutolo M, Strab RH (2000) Recent aspects of gonadal hormone and neurotrasmitter interaction with synovial and immune cells: implication in rheumatoid arthritis. Ann Rheum Dis 59:657–661CrossRefPubMedGoogle Scholar
  11. 11.
    Bizzarro A, Valentini G, Di Martino G, Da ponte A, De Bellis A, Iacono G (1987) Influence of testosterone therapy on clinical and immunological features of autoimmune disease associated with Klinefelter’s syndrome. J Clin Endocrinol Metab 64(1):32–36PubMedGoogle Scholar
  12. 12.
    Harbuz MS, Korendowych E, Jessop DS, Crow AL, Lipdfan SL, Kirwan JR (2003) Hypothalamo–pituitary–adrenal axis dysregulation in patient with rheumatoid arthritis after the dexamethasone/corticotrophin releasing factor test. J Endocrinol 178(1):55–60CrossRefPubMedGoogle Scholar

Copyright information

© Clinical Rheumatology 2006

Authors and Affiliations

  • N. Melillo
    • 1
  • A. Corrado
    • 1
  • L. Quarta
    • 1
  • F. D’Onofrio
    • 1
  • F. P. Cantatore
    • 1
  1. 1.Department of RheumatologyUniversity of Foggia “D’Avanzo” HospitalFoggiaItaly

Personalised recommendations