Clinical Rheumatology

, Volume 25, Issue 5, pp 687–693 | Cite as

Treatment of complex regional pain syndrome type I of the hand with a series of intravenous regional sympathetic blocks with guanethidine and lidocaine

  • Kosmas I. ParaskevasEmail author
  • Alexandra A. Michaloglou
  • Despina D. Briana
  • Maria Samara
Original Article


The aim of this study was to evaluate the efficacy of guanethidine and lidocaine in the treatment of complex regional pain syndrome (CRPS) type I of the hand. Seventeen patients, aged between 33 and 72 years, suffering from CRPS type I of the hand received two series of intravenous regional sympathetic block (Bier's block) sessions with guanethidine and lidocaine according to the following therapeutic protocol: (1) 5 sessions (once every second day) composed of intravenous regional administration of 15 mg guanethidine and 1 mg lidocaine/kg body weight each and (2) 20 sessions (twice a week) composed of intravenous regional administration of 10 mg guanethidine and 1 mg lidocaine/kg body weight each. Complete disappearance of pain and return of the normal function and movement of the extremity were achieved. No side effects were observed. The above-described therapeutic protocol method resulted in excellent pain relief and full restoration of both function and range of movement of the affected extremity in 17 patients suffering from CRPS type I of the hand.


Allodynia Bier's block Complex regional pain syndrome type I Hyperalgesia Intravenous regional guanethidine administration 


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Copyright information

© Clinical Rheumatology 2005

Authors and Affiliations

  • Kosmas I. Paraskevas
    • 1
    • 4
    Email author
  • Alexandra A. Michaloglou
    • 2
  • Despina D. Briana
    • 3
  • Maria Samara
    • 2
  1. 1.Department of Vascular SurgeryAthens University Medical SchoolAthensGreece
  2. 2.Department of AnesthesiologyGeneral Prefecture Hospital of LarissaLarissaGreece
  3. 3.Athens University Medical SchoolAthensGreece
  4. 4. AthensGreece

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