Clinical Rheumatology

, 25:542 | Cite as

Anti-topoisomerase I antibodies in systemic lupus erythematosus as a marker of severe nephritis

  • Mohamed A. Hamidou
  • Marie A. Audrain
  • Agathe Masseau
  • Christian Agard
  • Anne Moreau
Brief Report


The authors report nine patients with systemic lupus erythematosus associated with anti-topoisomerase I antibodies (ELISA test) without features of systemic sclerosis. These antibodies were correlated with the disease activity and might be a marker of the severity of the closely related to difusse proliferative glomerulonephritis.


Anti-topoisomerase I antibodies Systemic lupus erythematosus Systemic sclerosis 


  1. 1.
    Gussin HAE, Ignat GP, Varga J, Teodorescu M (2001) Anti-topoisomerase I (anti-Scl-70) antibodies in patients with systemic lupus erythematosus. Arthritis Rheum 44:376–383CrossRefPubMedGoogle Scholar
  2. 2.
    Mukai M, Sagawa A, Atsumi T et al (1993) Three cases of anti-Scl-70 (topoisomerase I) antibody associated with central nervous system lupus without renal disorder. J Rheumatol 20:1594–1597PubMedGoogle Scholar
  3. 3.
    Stojanov L, Satoh M, Dooley MA, Kuwana M, Jennette JC, Reeves WH (1995) Autoantibodies to topoisomerase I in a patient with systemic lupus erythematosus without features of scleroderma. Lupus 4:314–317PubMedCrossRefGoogle Scholar
  4. 4.
    Watanabe T, Tsuchida T, Kanda N, Tamaki K (1997) Avascular necrosis of bone in systemic lupus erythematosus : the predictive role of precipitating autoantibodies. Scand J Rheumatol 26:184–187PubMedCrossRefGoogle Scholar
  5. 5.
    Al Attia HM, D'Souza MS (2003) Antitopoisomerase I antibody in patients with systemic lupus erythematosus/sicca syndrome without a concomitant scleroderma: two case reports. Clin Rheumatol 22:70–72CrossRefPubMedGoogle Scholar
  6. 6.
    Ignat GP, Rat A-C, Sychra JJ, Vo J, Varga J, Teodorescu M (2003) Information on diagnosis and management of systemic lupus erythematosus derived from the routine measurement of 8 nuclear autoantibodies. J Rheumatol 30:1761–1769PubMedGoogle Scholar
  7. 7.
    Yee CS, Hussein H, Skan J, Bowman S, Situnayake D, Gordon C (2003) Association of damage with autoantibody profile, age, race, sex and disease duration in systemic lupus erythematosus. Rheumatology 42:276–279CrossRefPubMedGoogle Scholar

Copyright information

© Clinical Rheumatology 2006

Authors and Affiliations

  • Mohamed A. Hamidou
    • 1
  • Marie A. Audrain
    • 2
  • Agathe Masseau
    • 1
  • Christian Agard
    • 1
  • Anne Moreau
    • 3
  1. 1.Department of Internal MedicineUniversity Hospital Hôtel-DieuNantesFrance
  2. 2.Laboratory of ImmunologyUniversity Hospital Hôtel-DieuNantesFrance
  3. 3.Laboratory of PathologyUniversity Hospital Hôtel-DieuNantesFrance

Personalised recommendations