Clinical Rheumatology

, Volume 25, Issue 4, pp 537–539

Abnormalities in the bone mineral metabolism in HIV-infected patients

  • A. M. García Aparicio
  • S. Muñoz Fernández
  • J. González
  • J. R. Arribas
  • J. M. Peña
  • J. J. Vázquez
  • M. E. Martínez
  • J. Coya
  • E. Martín Mola
Brief Report

DOI: 10.1007/s10067-005-0028-x

Cite this article as:
García Aparicio, A.M., Muñoz Fernández, S., González, J. et al. Clin Rheumatol (2006) 25: 537. doi:10.1007/s10067-005-0028-x

Abstract

Objective

To evaluate bone mineral metabolism in HIV infected and asymptomatic patients receiving highly active antiretroviral therapy (HAART) containing protease inhibitors (PI) and naïve patients.

Methods

We studied 30 asymptomatic HIV infected male patients, 13 in the naive group and 17 in the IP group, both without differences in demographics characteristics. We excluded women and patients with any known factor associated to osteopenia. We did a nutritional questionnaire, a DEXA scan in lumbar spine and femur, a study of CD4 lymphocytes, viral load and an analysis of bone formation and resorption markers in all patients. We compared vitamin D and PTH levels with a control group of healthy male volunteers age-pareated. For the statistical analysis we used the SPSS program.

Results

Osteopenia was present in 17/30 (57%), 8/13 (61.5%) in the naïve group and 9/17 (53%) in the PI group (not significant differences). We found a vitamin D deficiency in 86% of patients, with mean serum levels that was found to be significantly lower than those from a healthy control group (p=0.04). Testosterone level was significantly related to bone mineral density in lumbar spine (p≤0.05).

Conclusions

HIV may be an individual risk factor in bone disorders, requiring calcium and vitamin D supplementation.

Keywords

HAART HIV Osteopenia Osteoporosis Vitamin D 

Copyright information

© Clinical Rheumatology 2005

Authors and Affiliations

  • A. M. García Aparicio
    • 1
  • S. Muñoz Fernández
    • 2
  • J. González
    • 3
  • J. R. Arribas
    • 3
  • J. M. Peña
    • 3
  • J. J. Vázquez
    • 3
  • M. E. Martínez
    • 4
  • J. Coya
    • 5
  • E. Martín Mola
    • 2
  1. 1.Rheumatology UnitHospital Virgen de la SaludToledoSpain
  2. 2.Rheumatology UnitHospital Universitario La PazMadridSpain
  3. 3.Internal MedicineHospital Universitario La PazMadridSpain
  4. 4.Biochemistry UnitHospital Universitario La PazMadridSpain
  5. 5.Nuclear MedicineHospital Universitario La PazMadridSpain

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