Clinical Rheumatology

, Volume 24, Issue 2, pp 134–138 | Cite as

Arterial distensibility as determined by carotid-femoral pulse wave velocity in patients with Behçet’s disease

  • Turhan Kürüm
  • Mustafa Yıldız
  • Mehmet Soy
  • Gültaç Özbay
  • Levent Alimgil
  • Binnur Tüzün
Original Article

Abstract

Behçet’s disease (BD) is a chronic, multisystem disorder characterized by genital and oral aphthae, skin lesions, uveitis, and tendency to thrombosis. Pulse wave velocity (PWV) is an important factor in determining cardiovascular mortality and morbidity. It is an index of arterial wall stiffness and inversely related to the arterial distensibility. In this study we investigated the arterial distensibility in BD by PWV. We studied 14 patients with BD (18–44 years old, 10 men) and 28 healthy subjects (18–39 years old, 21 men) without known cardiovascular disease. Arterial distensibility was assessed by automatic carotid-femoral PWV measurement using the Complior Colson device. PWV is calculated from measurements of pulse transit time and the distance traveled by the pulse between two recording sites, according to the following formula: pulse wave velocity (m/s)=distance (m)/transit time(s). The mean ages, systolic blood pressure, diastolic blood pressure, pulse pressure, heart rate, and PWV of Behçet’s disease and control subjects were 32.1±7.4 vs 27.9±6.1 years, 112.9±12.0 vs 108.7±10.0 mmHg, 72.1±10.7 vs 67.7±7.5 mmHg, 40.7±12.2 vs 41.0±10.7 mmHg, 74.1±10.2 vs 77.2±10.1 bpm, and 8.4±1.4 vs 8.5±1.1 m/s, respectively. Differences between all parameters studied were not found to be statistically significant (p>0.05). The carotid-femoral PWV, an index of arterial stiffness and a marker of atherosclerosis, is not increased in patients with BD compared with control subjects.

Keywords

Arterial distensibility Behçet’s disease Pulse wave velocity 

References

  1. 1.
    Sakane T, Takeno M, Suzuki N, Inaba G (1999) Behçet’s disease. N Engl J Med 341:1284–1291CrossRefPubMedGoogle Scholar
  2. 2.
    Koc Y, Gullu I, Akpek G, Akpolat T, Kansu E, Kiraz S, Batman F, Kansu T, Balkanci F, Akkaya S et al (1992) Vascular involvement in Behçet’s disease. J Rheumatol 19:402–410PubMedGoogle Scholar
  3. 3.
    O’Duffy JD (1990) Vasculitis in Behçet’s disease. Rheum Dis Clin North Am 16:423–431Google Scholar
  4. 4.
    Niwa Y, Miyake S, Sakane T, Shingu M, Yokoyama M (1982) Auto-oxidative damage in Behçet’s disease—endothelial cell damage following the elevated oxygen radicals generated by stimulated neutrophils. Clin Exp Immunol 49:247–255PubMedGoogle Scholar
  5. 5.
    Freitas JP, Filipe P, Yousefi A, Emerit I, Guerra Rodrigo F (1998) Oxidative stress in Adamantiades-Behçet’s disease. Dermatology 197:343–348CrossRefPubMedGoogle Scholar
  6. 6.
    Orem A, Deger O, Cimsit G, Karahan SC, Akyol N, Yildirmis S (1995) Plasma lipoprotein(a) and its relationship with disease activity in patients with Behçet’s disease. Eur J Clin Chem Clin Biochem 33:473–478PubMedGoogle Scholar
  7. 7.
    Orem A, Cimsit G, Deger O, Vanizor B, Karahan SC (1999) Autoantibodies against modified low-density lipoprotein in patients with Behçet’s disease. Dermatology 198:243–246PubMedGoogle Scholar
  8. 8.
    Orem A, Efe H, Deger O, Cimsit G, Uydu HA, Vanizor B (1997) Relationship between lipid peroxidation and disease activity in patients with Behçet’s disease. J Dermatol Sci 16:11–16CrossRefPubMedGoogle Scholar
  9. 9.
    Yazici H, Basaran G, Hamuryudan V, Hizli N, Yurdakul S, Mat C, Tuzun Y, Ozyazgan Y, Dimitriyadis I (1996) The ten-year mortality in Behçet’s syndrome. Br J Rheumatol 35:139–141PubMedGoogle Scholar
  10. 10.
    Kural-Seyahi E, Fresko I, Seyahi N, Ozyazgan Y, Mat C, Hamuryudan V, Yurdakul S, Yazici H (2003) The long-term mortality and morbidity of Behçet’s syndrome: a 2-decade outcome survey of 387 patients followed at a dedicated center. Medicine (Baltimore) 82:60–76Google Scholar
  11. 11.
    Klocke R, Cockcroft JR, Taylor GJ, Hall IR, Blake DR (2003) Arterial stiffness and central blood pressure, as determined by pulse wave analysis, in rheumatoid arthritis. Ann Rheum Dis 62:414–418CrossRefPubMedGoogle Scholar
  12. 12.
    Van Doornum S, McColl G, Jenkins A, Green DJ, Wicks IP (2003) Screening for atherosclerosis in patients with rheumatoid arthritis: comparison of two in vivo tests of vascular function. Arthritis Rheum 48:72–80CrossRefPubMedGoogle Scholar
  13. 13.
    Wong M, Toh L, Wilson A, Rowley K, Karschimkus C, Prior D, Romas E, Clemens L, Dragicevic G, Harianto H, Wicks I, McColl G, Best J, Jenkins A (2003) Reduced arterial elasticity in rheumatoid arthritis and the relationship to vascular disease risk factors and inflammation. Arthritis Rheum 48:81–89CrossRefPubMedGoogle Scholar
  14. 14.
    Selzer F, Sutton-Tyrrell K, Fitzgerald S, Tracy R, Kuller L, Manzi S (2001) Vascular stiffness in women with systemic lupus erythematosus. Hypertension 37:1075–1082PubMedGoogle Scholar
  15. 15.
    Simon A, Levenson J (2001) Effect of hypertension on viscoelasticity of large arteries in humans. Curr Hypertension Rep 3:74–78Google Scholar
  16. 16.
    Imura T, Yamamoto K, Kanamori K, Mikami T, Yasuda H (1986) Noninvasive ultrasonic measurement of the elastic properties of the human abdominal aorta. Cardiovasc Res 20:208–214PubMedGoogle Scholar
  17. 17.
    Wilkinson IB, Webb DJ, Cockroft JR (1999) Aortic pulse-wave velocity. Lancet 354:1996–1997CrossRefGoogle Scholar
  18. 18.
    Oren A, Vos LE, Uiterwaal CS, Grobee DE, Bots ML (2003) Aortic stiffness and carotid intima-media thickness: two independent markers of subclinical vascular damage in young adults. Eur J Clin Invest 33:949–954CrossRefPubMedGoogle Scholar
  19. 19.
    International Study Group for Behçet’s Disease (1990) Criteria for diagnosis of Behçet’s disease. Lancet 335:1078–1080PubMedGoogle Scholar
  20. 20.
    Asmar R, Benetos A, Topouchian J, Laurent P, Pannier B, Brisac AM, Target R, Levy BI (1995) Assessment of arterial distensibility by automatic pulse wave velocity measurement: validation and clinical application studies. Hypertension 26:485–490PubMedGoogle Scholar
  21. 21.
    Chambers JC, Haskard DO, Kooner JS (2001) Vascular endothelial function and oxidative stress mechanisms in patients with Behçet’s syndrome. J Am Coll Cardiol 37:517–520CrossRefPubMedGoogle Scholar
  22. 22.
    Joannides R, Haefeli WE, Linder L, Richard V, Bakkali EH, Thuillez C, Luscher TF (1995) Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation 91:1314–1319PubMedGoogle Scholar
  23. 23.
    Muftuoglu AU, Yazici H, Yurdakul S, Tuzun Y, Pazarli H, Gungen G, Deniz S (1986) Behçet’s disease. Relation of serum C-reactive protein and erythrocyte sedimentation rates to disease activity. Int J Dermatol 25:235–239PubMedGoogle Scholar

Copyright information

© Clinical Rheumatology 2004

Authors and Affiliations

  • Turhan Kürüm
    • 1
  • Mustafa Yıldız
    • 1
  • Mehmet Soy
    • 2
  • Gültaç Özbay
    • 1
  • Levent Alimgil
    • 3
  • Binnur Tüzün
    • 4
  1. 1.Department of Cardiology, School of MedicineTrakya UniversityEdirneTurkey
  2. 2.Department of Rheumatology, School of MedicineTrakya UniversityEdirneTurkey
  3. 3.Department of Ophthalmology, School of MedicineTrakya UniversityEdirneTurkey
  4. 4.Department of Dermatology, School of MedicineTrakya UniversityEdirneTurkey

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