Clinical Rheumatology

, Volume 22, Issue 4–5, pp 355–358 | Cite as

Systemic lupus erythematosus and thrombotic thrombocytopenic purpura: a case report and literature review

  • K. Hamasaki
  • T. Mimura
  • H. Kanda
  • K. Kubo
  • K. Setoguchi
  • T. Satoh
  • Y. Misaki
  • K. Yamamoto
Article

Abstract

We describe a patient with systemic lupus erythematosus (SLE) who developed severe and acute thrombotic thrombocytopenic purpura (TTP). Detection of the fragmentation of peripheral red blood cells (RBC) helped the early diagnosis of TTP and the patient was rescued by extensive plasma exchange started promptly after the diagnosis. Because manifestations of TTP are similar to those in SLE, it is sometimes difficult to make an accurate diagnosis of TTP in SLE patients. We emphasise here the significance of the early diagnosis of TTP by the observation of fragmented RBC and the intensive therapy, including plasma exchange, for this very severe condition.

Keywords

Plasma exchange SLE Plasmapheresis Thrombotic microangiopathy TTP 

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Copyright information

© Clinical Rheumatology 2003

Authors and Affiliations

  • K. Hamasaki
    • 1
  • T. Mimura
    • 1
    • 2
  • H. Kanda
    • 1
  • K. Kubo
    • 1
  • K. Setoguchi
    • 1
  • T. Satoh
    • 1
  • Y. Misaki
    • 1
  • K. Yamamoto
    • 1
  1. 1.University of TokyoTokyoJapan
  2. 2.Department of Rheumatology and Applied ImmunologySaitama Medical SchoolMoroyama-machi, IrumaJapan

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