Nanomaterials for cancer therapy and imaging
- 885 Downloads
A variety of organic and inorganic nanomaterials with dimensions below several hundred nanometers are recently emerging as promising tools for cancer therapeutic and diagnostic applications due to their unique characteristics of passive tumor targeting. A wide range of nanomedicine platforms such as polymeric micelles, liposomes, dendrimers, and polymeric nanoparticles have been extensively explored for targeted delivery of anti-cancer agents, because they can accumulate in the solid tumor site via leaky tumor vascular structures, thereby selectively delivering therapeutic payloads into the desired tumor tissue. In recent years, nanoscale delivery vehicles for small interfering RNA (siRNA) have been also developed as effective therapeutic approaches to treat cancer. Furthermore, rationally designed multi-functional surface modification of these nanomaterials with cancer targeting moieties, protective polymers, and imaging agents can lead to fabrication versatile theragnostic nanosystems that allow simultaneous cancer therapy and diagnosis. This review highlights the current state and future prospects of diverse biomedical nanomaterials for cancer therapy and imaging.
Keywordscancer therapy drug delivery system imaging nanoparticles small interfering RNA
Unable to display preview. Download preview PDF.
- Denekamp, J. (1984). Vasculature as a target for tumour therapy. Prog. Appl. Microcirc. 4, 28–38.Google Scholar
- Djojosubroto, M.W., Choi, Y.S., Lee, H.W., and Rudolph, K.L. (2003). Telomeres and telomerase in aging, regeneration and cancer. Mol. Cell 15, 164–175.Google Scholar
- Höbel, S., Koburger, I., John, M., Czubayko, F., Hadwiger, P., Vornlocher, H., and Aigner, A. (2010). Polyethylenimine/small interfering RNA-mediated knockdown of vascular endothelial growth factor in vivo exerts anti-tumor effects synergistically with Bevacizumab. J. Gene Med. 12, 287–300.PubMedGoogle Scholar
- Klibanov, A.L., Maruyama, K., Beckerleg, A.M., Torchilin, V.P., and Huang, L. (1991). Activity of amphipathic PEG 5000 to prolong the circulation time of liposomes depends on the liposome size and is unfavourable for immunoliposome binding to target. Biochem. Biophys. Acta 1062, 142–148.PubMedCrossRefGoogle Scholar
- Lee, S.H., Choi, S.H., Kim, S.H., and Park, T.G. (2008b). Thermally sensitive cationic polymer nanocapsules for specific cytosolic delivery and efficient gene silencing of siRNA: swelling induced physical disruption of endosome by cold shock. J. Control. Release 125, 25–35.PubMedCrossRefGoogle Scholar
- Mao, S., Neu, M., Germershaus, O., Merkel, O., Sitterberg, J., Bakowsky, U., and Kissel, T. (2006). Influence of polyethylene glycol chain length on the physicochemical and biological properties of poly(ethylenimine)-graft-poly(ethylene glycol) block copolymer/ siRNA polyplexes. Bioconjugate Chem. 17, 1209–1218.CrossRefGoogle Scholar