Molecules and Cells

, Volume 31, Issue 2, pp 175–180 | Cite as

State-dependent disruption of short-term facilitation due to overexpression of the apPDE4 supershort form in Aplysia

  • Deok-Jin Jang
  • Jin-A Lee
  • Yeon-Su Chae
  • Bong-Kiun Kaang
Article

Abstract

Phosphodiesterases (PDEs) play important roles in synaptic plasticity by regulating cAMP signaling in various organisms. The supershort, short, and long forms of Aplysia PDE4 (apPDE4) have been cloned, and the long form has been shown to play a crucial role in 5- hydroxytryptamine (5-HT)-induced synaptic plasticity in Aplysia. To address the role of the supershort form in 5-HT-induced synaptic plasticity in Aplysia, we overexpressed the apPDE4 supershort form in Aplysia sensory neurons. Consequently, 5-HT-induced hyperexcitability and short-term facilitation in nondepressed synapses were blocked. However, the supershort form did not inhibit 5-HT-induced short-term facilitation in highly depressed synapses. These results show that the supershort form plays an important role in 5-HT-induced synaptic plasticity and disrupts it mainly by impairing cAMP signaling in Aplysia.

Keywords

Aplysia depressed synapse PDE4 supershort form synaptic facilitation 

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Copyright information

© The Korean Society for Molecular and Cellular Biology and Springer Netherlands 2011

Authors and Affiliations

  • Deok-Jin Jang
    • 1
  • Jin-A Lee
    • 2
  • Yeon-Su Chae
    • 1
  • Bong-Kiun Kaang
    • 1
    • 3
  1. 1.National Creative Research Initiative Center for Memory, Departments of Biological Sciences, College of Natural SciencesSeoul National UniversitySeoulKorea
  2. 2.Department of Biotechnology, College of Life Science and Nano TechnologyHannam UniversityDaejeonKorea
  3. 3.Brain and Cognitive Sciences, College of Natural SciencesSeoul National UniversitySeoulKorea
  4. 4.Department of Applied Biology, College of Ecology and EnvironmentKyungpook National UniversitySangjuKorea

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