Molecules and Cells

, Volume 28, Issue 6, pp 583–588

Peroxiredoxin 6 promotes lung cancer cell invasion by inducing urokinase-type plasminogen activator via p38 kinase, phosphoinositide 3-kinase, and Akt

  • Seung Bum Lee
  • Jin-Nyoung Ho
  • Sung Hwan Yoon
  • Ga Young Kang
  • Sang-Gu Hwang
  • Hong-Duck Um
Article

DOI: 10.1007/s10059-009-0152-6

Cite this article as:
Lee, S.B., Ho, JN., Yoon, S.H. et al. Mol Cells (2009) 28: 583. doi:10.1007/s10059-009-0152-6

Abstract

The peroxiredoxin family of peroxidase has six mammalian members (Prx 1–6). Considering their frequent up-regulation in cancer cells, Prxs may contribute to cancer cells’ survival in face of oxidative stress. Here, we show that Prx 6 promotes the invasiveness of lung cancer cells, accompanied by an increase in the activity of phosphoinositide 3-kinase (PI3K), the phosphorylation of p38 kinase and Akt, and the protein levels of uPA. Functional studies reveal that these components support Prx 6-induced invasion in the sequence p38 kinase/PI3K, Akt, and uPA. The findings provide a new understanding of the action of Prx 6 in cancer.

Keywords

cancer cell signaling invasion peroxiredoxin 6 

Copyright information

© The Korean Society for Molecular and Cellular Biology and Springer Netherlands 2009

Authors and Affiliations

  • Seung Bum Lee
    • 1
  • Jin-Nyoung Ho
    • 1
  • Sung Hwan Yoon
    • 1
  • Ga Young Kang
    • 1
  • Sang-Gu Hwang
    • 1
  • Hong-Duck Um
    • 1
  1. 1.Laboratory of Radiation Tumor PhysiologyKorea Institute of Radiological and Medical SciencesSeoulKorea

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