Peroxiredoxin 6 promotes lung cancer cell invasion by inducing urokinase-type plasminogen activator via p38 kinase, phosphoinositide 3-kinase, and Akt
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- Lee, S.B., Ho, JN., Yoon, S.H. et al. Mol Cells (2009) 28: 583. doi:10.1007/s10059-009-0152-6
The peroxiredoxin family of peroxidase has six mammalian members (Prx 1–6). Considering their frequent up-regulation in cancer cells, Prxs may contribute to cancer cells’ survival in face of oxidative stress. Here, we show that Prx 6 promotes the invasiveness of lung cancer cells, accompanied by an increase in the activity of phosphoinositide 3-kinase (PI3K), the phosphorylation of p38 kinase and Akt, and the protein levels of uPA. Functional studies reveal that these components support Prx 6-induced invasion in the sequence p38 kinase/PI3K, Akt, and uPA. The findings provide a new understanding of the action of Prx 6 in cancer.