Molecules and Cells

, Volume 28, Issue 1, pp 7–12

Biology of glioma cancer stem cells



Gliomas, much like other cancers, are composed of a heterogeneous mix of neoplastic and non-neoplastic cells that include both native and recruited cells. There is extensive diversity among the tumor cells, with differing capacity for in vitro and in vivo growth, a property intimately linked to the cell’s differentiation status. Those cells that are undifferentiated, self-renewing, with the capacity for developing tumors (tumorigenic) cells are designated by some as cancer stem cells, because of the stem-like properties. These cells may be a critical therapeutic target. However the exact identity and cell(s) of origin of the so-called glioma cancer stem cell remain elusive. Here we review the current understanding of glioma cancer stem cell biology.


brain tumor cancer stem cell glioma glioblastoma 


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Copyright information

© The Korean Society for Molecular and Cellular Biology and Springer Netherlands 2009

Authors and Affiliations

  1. 1.University of Pittsburgh Cancer InstitutePittsburghUSA
  2. 2.Department of Neurological SurgeryUniversity of PittsburghPittsburghUSA
  3. 3.Department of Pharmacology and Chemical BiologyUniversity of PittsburghPittsburghUSA
  4. 4.Department of Stem Cell Biology and Regenerative MedicineCleveland ClinicClevelandUSA

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